Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine - Tapa blanda

Heng

 
9780443154287: Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine
Tapa blanda
ISBN 10: 0443154287 ISBN 13: 9780443154287
Editorial: Academic Press, 2025

Sinopsis

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.

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Acerca del autor

Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of seven international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Heng’s group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. Such experiments revealed that cancer evolution involves two phases: punctuated genome alteration-mediated macroevolution (which creates a new system), followed by stepwise gene and epigenetic-mediated microevolution (which leads to population growth). By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve genome-defined species identity information. Heng introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.

De la contraportada

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macroevolution. In authoring this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. In this fully updated, new edition Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research supporting Genome Architecture Theory. Ten evidence-based chapters discuss 4D genomics, genes, and genomes as distinct biological entities, genome chaos and macrocellular evolution, karyotype coding and fuzzy inheritance, as well as an entirely novel information flow-driven model of evolution, and more. All new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary theory. This synthesis offers an updated evolutionary theory, unifying physical, chemical, and biological mechanisms within organismal systems, and details the evolution of information packages where information flow, matter arrangement, and energy interact.

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Editorial
Academic Press
Año de publicación
2025
Idioma
Inglés
ISBN 10 
0443154287
ISBN 13 
9780443154287
Encuadernación
Tapa blanda
Número de edición
2
Número de páginas
750
Contacto del fabricante
Academic Press
https://shop.elsevier.com/

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