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Mammalian Heme Peroxidases: Diverse Roles in Health and Disease: 47 (Oxidative Stress and Disease) - Tapa dura

 
9780367820367: Mammalian Heme Peroxidases: Diverse Roles in Health and Disease: 47 (Oxidative Stress and Disease)
Tapa dura
ISBN 10: 0367820366 ISBN 13: 9780367820367
Editorial: CRC Press, 2021

Sinopsis

Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions.

Key Features

  • Structure and biosynthesis of mammalian peroxidases

  • Reactivity of hypohalous acids with biological substrates

  • Peroxidases in innate immunity

  • Peroxidases in human pathology
  • Modulation of peroxidase-induced biological damage

"Sinopsis" puede pertenecer a otra edición de este libro.

Acerca del autor

Clare Hawkins is a Professor in the Department of Biomedical Sciences, University of Copenhagen. She appointed in March 2017 after nearly 20 years in Sydney at the Heart Research Institute, where she held the position of Scientific Director and the Inflammation Group Leader. Clare is a former Australian Research Council Future Fellow, and Principal Research Fellow within Sydney Medical School, University of Sydney. She completed her PhD in Chemistry at the University of York (UK) before making the move to Sydney where she eventually became Head of the Inflammation Group at the Heart Research Institute. Her research is focused on understanding how chemical oxidants modulate cellular function under inflammatory conditions, and the role of these reactions in the pathogenesis of inflammatory diseases, including atherosclerosis. Prof Hawkins has been awarded prestigious Career Development Awards including a R. Douglas Wright Biomedical Fellowship from the National Health and Medical Research Council (NHMRC) of Australia in 2003, a Career Development Fellowship from the National Heart Foundation of Australia (NHF), and an Australian Research Council (ARC) Future Fellowship, together with project grants from both European and Australian funding agencies. She has authored several book chapters and about 100 peer-reviewed journal articles in high-quality, journals, attracting more than 5000 citations. William M. Nauseef is a professor in the Department of Microbiology at the University of Iowa. He also serves as the Director of the Inflammation Program, also at the University of Iowa. He received his MD from the SUNY Upstate Medical Center, Syracuse, New York. He is Board Certified by the American Board of Internal Medicine in Infectious Diseases. He is the author or co-author of over 180 peer reviewed papers, has co-authored 2 books, and co-authored dozens of book chapters. His research program over the past ~ four decades has focused on elucidating the cell and molecular biology of human neutrophils within the context of innate host defense against infection.

De la contraportada

Mammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although beneficial, overproduction drives development of pathologies, by triggering the initiation of stress-related cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, and their involvement in immunity and disease.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
CRC Press
Año de publicación
2021
Idioma
Inglés
ISBN 10 
0367820366
ISBN 13 
9780367820367
Encuadernación
Tapa dura
Número de edición
1
Número de páginas
328
Editor
Hawkins Clare, Nauseef William M
Contacto del fabricante
Taylor and Francis, GPSR Taylor and Francis
gpsr@taylorandfrancis.com

Taylor & Francis Verlag GmbH, Kaufingerstraße 24
München
80331
Alemania