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Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics Series) - Tapa blanda

Libro 90 de 155: Chapman & Hall/CRC Biostatistics

Wu, Jianrong

 
9780367734329: Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics Series)
Tapa blanda
ISBN 10: 036773432X ISBN 13: 9780367734329
Editorial: Routledge, 2020

Sinopsis

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials.

This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

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Acerca del autor

Jianrong (John) Wu is a professor in the Division of Cancer Biostatistics, Department of Biostatistics, Markey Cancer Center, University of Kentucky. He has more than 15 years’ experience of designing and conducting cancer clinical trials at St. Jude Children’s Research Hospital and has developed several novel statistical methods for designing phase II and phase III survival trials.

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Editorial
Routledge
Año de publicación
2020
Idioma
Inglés
ISBN 10 
036773432X
ISBN 13 
9780367734329
Encuadernación
Tapa blanda
Número de edición
1
Número de páginas
257
Contacto del fabricante
Taylor and Francis, GPSR Taylor and Francis
gpsr@taylorandfrancis.com

Taylor & Francis Verlag GmbH, Kaufingerstraße 24
München
80331
Alemania