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Randomised Response-Adaptive Designs in Clinical Trials (Monographs on Statistics and Applied Probability, 130) - Tapa blanda

Libro 44 de 110: ISSN

Atkinson, Anthony C; Biswas, Atanu

 
9780367378974: Randomised Response-Adaptive Designs in Clinical Trials (Monographs on Statistics and Applied Probability, 130)
Tapa blanda
ISBN 10: 0367378973 ISBN 13: 9780367378974
Editorial: Routledge, 2019

Sinopsis

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.

After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

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Acerca del autor

Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science.

Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.

De la contraportada

This book presents methods for the randomized allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. The authors compare various designs of clinical trials, include real examples of clinical trials, and present simulations of many procedures for small to moderate-sized samples. They also use results from the optimum design of experiments to create powerful and flexible adaptive designs.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Routledge
Año de publicación
2019
Idioma
Inglés
ISBN 10 
0367378973
ISBN 13 
9780367378974
Encuadernación
Tapa blanda
Número de edición
1
Número de páginas
340
Contacto del fabricante
Taylor and Francis, GPSR Taylor and Francis
gpsr@taylorandfrancis.com

Taylor & Francis Verlag GmbH, Kaufingerstraße 24
München
80331
Alemania