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Sinopsis
Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.
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Críticas
`One of the basic principles of physical chemistry concerns the characterization of compounds. Indeed, physical chemists make good collaborators with synthetic organic chemists in that the physikers know how to study the new compounds that the organikers continually synthesize. [...] In his short introductory chapter, the author discusses why one would want to characterize compounds, at what point during development should the compounds be characterized, and what methodologies constitute charcterization investigations. In the next two concise and tidy chapters, the authors outlines a number of basic concepts associated with themordynamics and kinetics. [...] So who should buy this book? There is no doubt that the volume constitutes an excellent source of information for graduate students because its broad focus cuts across so many fields that it can serve as a supplement to various courses. The empirical aspects will be useful to pharamceutical workers who need a shortcut to a viable experimental protocol and who do not have the time to research the literature.'
Pharmaceutical Development and Technology, 8:3 (2003)
Reseña del editor
Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.
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Characterization of Compounds in Solution: Theory and Practice
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Characterization of Compounds in Solution : Theory and Practice
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Characterization of Compounds in Solution (Hardcover)
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Springer Science+Business Media, New York, 2001
ISBN 10: 0306465957
ISBN 13: 9780306465956
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Hardcover. Condición: new. Hardcover. While there are many topics which can be included in a discussion on solution properties of compounds, the following are the most critical in the area of pharmaceutics: equilibrium constants, partition coefficients, general solubility, solubility in protic solvents, and solution stability. The purpose of this text is to bring together these topics in a logical and concise manner. Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Nº de ref. del artículo: 9780306465956
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Characterization of Compounds in Solution: Theory and Practice
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Characterization of Compounds in Solution
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Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur. 300 pp. Englisch. Nº de ref. del artículo: 9780306465956
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Gebunden. Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such . Nº de ref. del artículo: 5903268
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Characterization of Compounds in Solution: Theory and Practice
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Springer Science+Business Media, 2001
ISBN 10: 0306465957
ISBN 13: 9780306465956
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Characterization of Compounds in Solution
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Springer US, Springer US Aug 2001, 2001
ISBN 10: 0306465957
ISBN 13: 9780306465956
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Buch. Condición: Neu. Neuware -Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 300 pp. Englisch. Nº de ref. del artículo: 9780306465956
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Characterization of Compounds in Solution : Theory and Practice
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Springer US, Springer US, 2001
ISBN 10: 0306465957
ISBN 13: 9780306465956
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Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur. Nº de ref. del artículo: 9780306465956
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