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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II: 22 (Environmental Science Research) - Tapa dura

 
9780306408908: Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II: 22 (Environmental Science Research)

Sinopsis

More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing.

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More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing.

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9781468441239: Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II: 22 (Environmental Science Research)

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ISBN 10:  146844123X ISBN 13:  9781468441239
Editorial: Springer, 2012
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Michael Waters, Stephen Nesnow, Joellen L. Huisingh, Shahbeg S. Sandhu, Larry Claxton
Publicado por Plenum, 1980
ISBN 10: 0306408902 ISBN 13: 9780306408908
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Condición: Good. 524 pp., hardcover, ex library, else text clean & binding tight. - If you are reading this, this item is actually (physically) in our stock and ready for shipment once ordered. We are not bookjackers. Buyer is responsible for any additional duties, taxes, or fees required by recipient's country. Nº de ref. del artículo: ZB579443

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Symposium on the Application of Short-Term Bioassays in the Fractionat;Waters, Michael
ISBN 10: 0306408902 ISBN 13: 9780306408908
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Librería: Vashon Island Books, Vashon, WA, Estados Unidos de America

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Hardcover. Condición: Very Good. Estado de la sobrecubierta: No Dust Jacket. First Edition. Series: Environmental Science Research: Volume 22. (light shelfwear, rubbing, nicks to jacket extremities, name to endpaper). Size: 8vo - over 7¾" - 9¾". Book. Nº de ref. del artículo: 0806401

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Symposium on the Application of Short-Term Bioassays in the Fractionat;Waters, Michael
ISBN 10: 0306408902 ISBN 13: 9780306408908
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Librería: Vashon Island Books, Vashon, WA, Estados Unidos de America

Calificación del vendedor: 5 de 5 estrellas Valoración 5 estrellas, Más información sobre las valoraciones de los vendedores

Hardcover. Condición: Very Good. Estado de la sobrecubierta: No Dust Jacket. First Edition. Series: Environmental Science Research: Volume 22. (light shelfwear, rubbing, nicks to jacket extremities, name to endpaper). Size: 8vo - over 7¾" - 9¾". Book. Nº de ref. del artículo: 0806402

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Waters, Michael D. (editor); Sandhu, Shahbeg S. (editor); Huisingh, Joellen L. (editor); Claxton, Larry (editor); Nesnow, Stephen (editor)
Publicado por Plenum Press, [1983]., New York, 1983
ISBN 10: 0306408902 ISBN 13: 9780306408908
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Librería: Pride and Prejudice-Books, Ballston Lake, NY, Estados Unidos de America

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Hardcover. Condición: Very Good. First Edition. Original blue cloth. Ex-library with the usual markings else Very Good. No Dust Jacket. Nº de ref. del artículo: 013374

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Publicado por Springer, 1981
ISBN 10: 0306408902 ISBN 13: 9780306408908
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Librería: dsmbooks, Liverpool, Reino Unido

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hardcover. Condición: Good. Good. book. Nº de ref. del artículo: D8S0-3-M-0306408902-3

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