Molecular Biology: Principles of Genome Function

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9780199658572: Molecular Biology: Principles of Genome Function

The biological world operates on a multitude of scales - from molecules to tissues to organisms to ecosystems. Throughout these myriad levels runs a common thread: the communication and onward passage of information, from cell to cell, from organism to organism and ultimately, from generation to generation. But how does this information come alive to govern the processes that constitute life? The answer lies in the molecular components that cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology.

Molecular Biology: Principles of Genome Function, Second Edition, offers a fresh approach to the teaching of molecular biology by focusing on the commonalities that exist between the three kingdoms of life, and discussing the differences between the three kingdoms to offer instructive insights into molecular processes and components. This gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity. Additionally, an integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics

As an experimental science, molecular biology requires an appreciation for the approaches taken to yield the information from which concepts and principles are deduced. Experimental Approach panels throughout the text describe research that has been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Molecular Biology further enriches the learning experience with full-color artwork, end-of-chapter questions and summaries, suggested further readings grouped by topic, and an extensive glossary of key terms.

Features:
A focus on the underlying principles of molecular biology equips students with a robust conceptual framework on which to build their knowledge
An emphasis on their commonalities reflects the processes and components that exist between bacteria, archae, and eukaryotes
Experimental Approach panels demonstrate the importance of experimental evidence by describing research that has been particularly valuable in the field

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About the Author:


Nancy L Craig is Professor and Howard Hughes Medical Institute Investigator at the Johns Hopkins University School of Medicine. She is a recipient of the Johns Hopkins University Alumni Association Excellence in Teaching Award, as well as a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.

Orna Cohen-Fix is a Senior Investigator at the National Institute of Diabetes and Digestive and Kidney Diseases, Adjunct Professor at Johns Hopkins University, and the Co-Director of the NIH/Johns Hopkins University Graduate Partnership Program. She is the recipient of a Presidential Early Career Award for Scientists and Engineers and an Association of Women in Science Mentoring Award for her work on promoting the retention of women in science.

Rachel Green is Professor of Molecular Biology and Genetics at and Howard Hughes Medical Institute Investigator the Johns Hopkins University School of Medicine, and a member of the National Academy of Sciences. She is the recipient of a Johns Hopkins University School of Medicine Graduate Teaching Award.

Nobel Laureate Carol Greider is Professor and Director of the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. She is a member of the National Academy of Sciences and is the recipient of numerous awards, including the Gairdner Foundation International Award, the Louisa Gross Horwitz Prize, and the Lasker Award for Basic Medical Research. In 2009, she was awarded the Nobel Prize in Physiology or Medicine together with Elizabeth Blackburn and Jack Szostak for the discovery of telomerase.
Gisela Storz is a Senior Investigator at the National Institute of Child Health and Human Development. She is a Fellow of the American Academy of Microbiology, American Academy of Arts and Sciences, and National Academy of Sciences, and a recipient of the American Society for Microbiology Eli Lilly Award.

Cynthia Wolberger is Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine. She is a Fellow of the American Association for the Advancement of Science and a recipient of the Dorothy Crowfoot Hodgkin Award of the Protein Society.

Review:

Review from previous edition: "While I rarely make textbooks the core of my teaching material, the general presentation of material and interleaving of research results and methods is very similar to my preferred teaching strategy. That is what led me to adopt this remarkable textbook for use
in my class."
--Richard S. Myers, University of Miami

"I believe the strengths of the text are the organization and layout, with simple diagrams and headings that make mental organization easier for the students."
--Julia Frugoli, Clemson University

"I am delighted with Molecular Biology: Principles of Genome Function. It explains material extremely well. It has a nice balance of detail and focus on understanding the overall process. It is fantastically up to date."
--Barbara C. Hoopes, Colgate University - Hamilton, NY

"I would highly recommend this book to any colleague who was considering instituting a basic class in molecular biology."
--Andrew J. Andres, University of Nevada - Las Vegas

"Sobre este título" puede pertenecer a otra edición de este libro.

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Descripción Oxford University Press, United Kingdom, 2014. Paperback. Estado de conservación: New. 2nd Revised edition. Language: English . Brand New Book. The biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life? The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered.It is written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend.Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline.Online Resource Centre The Online Resource Centre to accompany Molecular Biology: Principles of Genome Function features For registered adopters of the text: Electronic artwork: Figures from the book are available to download, for use in lectures. Journal Club: Suggested research papers and discussion questions linked to topics featured in the book build on the Experimental Approach panels in the book itself, to guide the process of assimilating knowledge from the research literature Answers to end of chapter. Nº de ref. de la librería AOP9780199658572

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