"Clear protocols are provided in sufficient detail to be attempted without additional research, and are easily distinguishable from the main text." Heredity
"This is the much needed and awaited update of a cytogenetics reference last published in 1992 ... Both volumes of this 3rd rdition are outstanding contributions to the practice of clinical cytogenetics and should be fixtures in every cytogentics laboratory. The editor will be pleased to note (as she mentioned in her preface) that my copies sit prominently on my desk and are severely "dog-eared"" ( Kent E Opheim, PhD, Children's Hospital and Regional Medical Center)
The advent of molecular technologies has lead to a rapid acceleration in the cytogenetic study of malignancy and acquired abnormalities. As well as having a chapter devoted to molecular technologies (FISH, PRINS, and CGH), molecular methodology is emphasized in all chapters, for example the role of CGH in solid tumour cytogenetics. Classical techniques are not forgotten, with a detailed description of the preparation and analysis of chromosomes from bone marrow and leukaemic blood. This is followed by three chapters on the specific methodology for the cytogenetic study of myeloid leukaemia, acute lymphoblastic leukaemia, and lymphomas and lymphoproliferative disorders. Also covered are chromosome instability syndromes, mutagen-induced chromosome damage in lymphocytes and the role of cytogenetics in the assessment of haematological disorders. This book will be invaluable to any scientists using cytogenetics to study malignancy and along with its sister volume Human Cytogenetics: Constitutional Analysis will be an essential purchase for any cytogenetics laboratory. The volumes are available individually or as a set.
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