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Nuclear Receptors: A Practical Approach: 207 (Practical Approach Series) - Tapa blanda

 
9780199637423: Nuclear Receptors: A Practical Approach: 207 (Practical Approach Series)
Tapa blanda
ISBN 10: 0199637423 ISBN 13: 9780199637423
Editorial: OUP Oxford, 1995

Sinopsis

The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.

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Críticas

"... An authoritative and wide-ranging 'methods' book in a distinguished series"Aslib Book Guide

"Dr Picard has done an excellent job in bringing together a range of exciting techniques that are currently being used to futher our understanding of this fascinating and ever growing family of 'Nuclear Recptors"Cell Biology International

Reseña del editor

The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
OUP Oxford
Año de publicación
1995
Idioma
Inglés
ISBN 10 
0199637423
ISBN 13 
9780199637423
Encuadernación
Tapa blanda
Número de edición
2
Número de páginas
304
Editor
Picard Didier
Contacto del fabricante
no disponible
Persona responsable
Ufficio Anagrafiche Messaggerie
ufficio.anagrafiche@meli.it

Via Verdi, 8
Assago Milano
20090
Italia