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Sinopsis
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"For researchers who need to define the regions of antigens that make contact with the antigen-binding site of antibodies or T- cell receptors, specialists explain the epitope mapping technique, which can also be adapted to identify regions on other ligands in their interactions with receptors. They assume no previous exposure to the approach, and though expect readers to have some familiarity with immunological techniques in general, are careful to point to the basic literature."--SciTech Book News
Reseña del editor
Epitope Mapping covers all the major methods for the identification and definition of epitopes. The Pepscan assay is used to define B cell epitopes and makes use of synthetic peptides but can only be used if the amino acid sequence is known. It can be adapted for the delineation of both helper T cells and cytotoxic T cells. The identification of combined B and T cell epitopes can also be achieved using synthetic peptides. There are other methodologies for analysing for cytotoxic T cell epitopes such as the purification of antigens presented by M.H.C. class I molecules and expression cloning. Site directed mutagenesis is also a powerful tool in epitope mapping and can be used to evaluate the role of single amino acids in immune complex formation. Protein footprinting makes use of monoclonal antibodies produced by hybridoma technology and relies on the fact that the epitope is protected from cleavage when bound as an antibody-antigen complex. It is only useful for small antigens. Other monoclonal antibody assays such as enzyme linked immunosorbent assay and haemaglutination and slot-blotting may also be used in epitope mapping. Random phage display libraries bring together the genetic and amino acid peptide sequence and can be screened with antibody and the resulting peptide D.N.A. sequenced to confirm the amino acid sequence of a specific epitope. Investigation of carbohydrates can also be useful to epitope mapping as deglycosylation can lead to loss of antigenic activity. Epitopes are important to the pharmaceutical industry and wherever appropriate, pharmaceutical applications of the methods described are included. For each method there is a description of the technology, protocols, trouble-shooting, and advice on when to use the method. This book will therefore be invaluable to any researcher involved in epitope mapping.
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- EditorialOxford University Press, U.S.A.
- Año de publicación1986
- ISBN 10 0199636524
- ISBN 13 9780199636525
- EncuadernaciónTapa blanda
- IdiomaInglés
- Número de páginas304
- EditorWestwood Olwyn M. R.
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EPITOPE MAPPING: A PRACTICAL APPROACH.
Publicado por
OUP, Bath Press, Avon, 2008
ISBN 10: 0199636524
ISBN 13: 9780199636525
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Librería: First Landing Books & Arts, Virginia Beach, VA, Estados Unidos de America
Calificación del vendedor: 5 de 5 estrellas
Soft cover. Condición: Very Good. Estado de la sobrecubierta: Not Issued. 1st. 284 pp including index. Epitope mapping covers the major methods for the identifaction and definition of epitopes. Size: 4to - over 9¾" - 12" tall. Book. Nº de ref. del artículo: 53702
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Epitope Mapping: A Practical Approach: 248 (Practical Approach Series)
Publicado por
Oxford University Press, U.S.A., 2001
ISBN 10: 0199636524
ISBN 13: 9780199636525
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Librería: WeBuyBooks, Rossendale, LANCS, Reino Unido
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Condición: Very Good. Most items will be dispatched the same or the next working day. A copy that has been read, but is in excellent condition. Pages are intact and not marred by notes or highlighting. The spine remains undamaged. Nº de ref. del artículo: wbs7452354580
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Epitope Mapping
Publicado por
Oxford University Press, 2001
ISBN 10: 0199636524
ISBN 13: 9780199636525
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Tapa blanda
Librería: OM Books, Sevilla, SE, España
Calificación del vendedor: 5 de 5 estrellas
Condición: Usado - bueno. Nº de ref. del artículo: 9780199636525
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Epitope Mapping: A Practical Approach (Practical Approach Series (Paperback))
Publicado por
Oxford University Press, USA, 2001
ISBN 10: 0199636524
ISBN 13: 9780199636525
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Librería: Mispah books, Redhill, SURRE, Reino Unido
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Paperback. Condición: Like New. Like New. book. Nº de ref. del artículo: ERICA75801996365246
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