Glycidamide-induced expression signature

ISBN 10: 383810630X / ISBN 13: 9783838106304
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Sinopsis: Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure.

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Título: Glycidamide-induced expression signature
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1.

Flurina Christina;Dip Clement
Editorial: Südwestdeutscher Verlag Für Hochschulschriften (2009)
ISBN 10: 383810630X ISBN 13: 9783838106304
Usado Taschenbuch Cantidad: 1
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Rheinberg-Buch
(Bergisch Gladbach, Alemania)
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Descripción Südwestdeutscher Verlag Für Hochschulschriften, 2009. Taschenbuch. Estado de conservación: Gebraucht. Gebraucht - Wie neu Leichte Lagerspuren - Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. 56 pp. Deutsch. Nº de ref. de la librería INF1000912541

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Flurina Christina Clement, Ramiro Dip, Hanspeter Naegeli
Editorial: Sudwestdeutscher Verlag Fur Hochschulschriften AG 2009-05-04 (2009)
ISBN 10: 383810630X ISBN 13: 9783838106304
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Descripción Sudwestdeutscher Verlag Fur Hochschulschriften AG 2009-05-04, 2009. paperback. Estado de conservación: New. Nº de ref. de la librería 9783838106304

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Clement, Flurina Christina / Dip, Ramiro
ISBN 10: 383810630X ISBN 13: 9783838106304
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Descripción Estado de conservación: New. Publisher/Verlag: Südwestdeutscher Verlag für Hochschulschriften | Transcriptional fingerprint of glycidamide, the reactive metabolite of the widespread food carcinogen acrylamide | Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. | Format: Paperback | 91 gr | 220x150x3 mm | 56 pp. Nº de ref. de la librería K9783838106304

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Flurina Christina Clement
Editorial: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015 (2015)
ISBN 10: 383810630X ISBN 13: 9783838106304
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Descripción Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015. Taschenbuch. Estado de conservación: Neu. 220x150x3 mm. Neuware - Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. 56 pp. Deutsch. Nº de ref. de la librería 9783838106304

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Flurina Christina Clement
Editorial: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015 (2015)
ISBN 10: 383810630X ISBN 13: 9783838106304
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Descripción Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015. Taschenbuch. Estado de conservación: Neu. 220x150x3 mm. This item is printed on demand - Print on Demand Neuware - Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. 56 pp. Deutsch. Nº de ref. de la librería 9783838106304

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Flurina Christina Clement
Editorial: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015 (2015)
ISBN 10: 383810630X ISBN 13: 9783838106304
Nuevos Taschenbuch Cantidad: 1
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Rheinberg-Buch
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Descripción Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015. Taschenbuch. Estado de conservación: Neu. 220x150x3 mm. Neuware - Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. 56 pp. Deutsch. Nº de ref. de la librería 9783838106304

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Flurina Christina Clement
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Descripción Sudwestdeutscher Verlag Fur Hochschulschriften AG, 2009. PAP. Estado de conservación: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. de la librería LQ-9783838106304

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Clement, Flurina Christina
Editorial: Südwestdeutscher Verlag für Hochschulschriften (2016)
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Descripción Südwestdeutscher Verlag für Hochschulschriften, 2016. Paperback. Estado de conservación: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Nº de ref. de la librería ria9783838106304_lsuk

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Flurina Christina Clement
Editorial: Sudwestdeutscher Verlag Fur Hochschulschriften AG (2009)
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Descripción Sudwestdeutscher Verlag Fur Hochschulschriften AG, 2009. PAP. Estado de conservación: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. de la librería IQ-9783838106304

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Flurina Christina Clement, Ramiro Dip, Hanspeter Naegeli
Editorial: Sudwestdeutscher Verlag Fur Hochschulschriften AG, United States (2015)
ISBN 10: 383810630X ISBN 13: 9783838106304
Nuevos Paperback Cantidad: 1
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Descripción Sudwestdeutscher Verlag Fur Hochschulschriften AG, United States, 2015. Paperback. Estado de conservación: New. 229 x 152 mm. Language: English . Brand New Book. Recent findings of acrylamide in foods have sparked new interest in assessing human health hazards due to long-term exposure to this vinyl compound. Acrylamide is tumorigenic at high doses in rodents but cancer risk projections in the human population remain uncertain as the molecular pathogenesis of acrylamide at the low dietary uptake is not understood. The present work addresses the question whether transcriptional responses amplify the known genotoxicity of acrylamide. Using DNA microarrays and PCR validations, we assessed genome-wide messenger profiles induced in human cells by acrylamide and glycidamide, its more reactive metabolite. The expression changes are characterized by the up-regulation of cytoprotective factors including the GSH system and multiple antioxidants. Low-dose experiments indicate that EPHX1 represents the most sensitive biomarker for glycidamide exposure. At higher concentrations, glycidamide induces markers of tumor progression, while growth suppressors and cell adhesion molecules are down-regulated. These findings indicate that tumor-promoting transcriptional signatures may be expected only at higher doses that exceed the ordinary dietary exposure. Nº de ref. de la librería KNV9783838106304

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