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Descripción Gebunden. Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. provides a summary of the major concepts related to the design and use of PDE inhibitorsdescribes exciting ideas and developments that are currently emerging in this dynamic and important fieldwritten by leading authorities in the fieldCyclic nucleotide. Nº de ref. del artículo: 5051601
Descripción Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. 540 pp. Englisch. Nº de ref. del artículo: 9783642179686
Descripción Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. Nº de ref. del artículo: 9783642179686