Stimuli-sensitive Nanocarrier from Random Copolymers: Easy Alternative: Role Reversal of PEG

 
9783330081970: Stimuli-sensitive Nanocarrier from Random Copolymers: Easy Alternative: Role Reversal of PEG
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Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of novel stimuli-sensitive self-assembled polymeric micelle (PM) and polymersome (PS) from PEGylated random copolymers as an easy alternative source instead of synthetically more challenging block copolymers. These spontaneously formed stable nanocarriers from easily synthesized random copolymers can not only carry hydrophobic and/or hydrophilic drugs, but also show pH-sensitive release of encapsulated guest. The impact of different hydrophobe (fatty acid chain or cholesterol) content on PMs of hydrophobically modified amphiphilic random copolymers directs the most effective delivery system. The ionic (zwitterionic, cationic, and anionic) random copolymers without having any typical hydrophobe in the backbone form more biocompatible pH-sensitive PS, where PEG forms the bilayer. The cationic PSs are able to carry not only drugs, but also transfect genetic materials to the target site. In addition to pH-sensitivity, the anionic PSs can show glutathione-triggered release of encapsulated drug with disintegration of the vesicles.

Biografía del autor:

Partha Laskar: Research Associate - Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK. He received Ph.D. from the Department of Chemistry, Indian Institute of Technology Kharagpur, India and M.Sc. in Chemistry from Ramakrishna Mission Residential College, Narendrapur, University of Calcutta, India.

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Partha Laskar
Publicado por LAP Lambert Academic Publishing Mai 2017 (2017)
ISBN 10: 333008197X ISBN 13: 9783330081970
Nuevo Taschenbuch Cantidad disponible: 1
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BuchWeltWeit Inh. Ludwig Meier e.K.
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Descripción LAP Lambert Academic Publishing Mai 2017, 2017. Taschenbuch. Condición: Neu. Neuware - Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of novel stimuli-sensitive self-assembled polymeric micelle (PM) and polymersome (PS) from PEGylated random copolymers as an easy alternative source instead of synthetically more challenging block copolymers. These spontaneously formed stable nanocarriers from easily synthesized random copolymers can not only carry hydrophobic and/or hydrophilic drugs, but also show pH-sensitive release of encapsulated guest. The impact of different hydrophobe (fatty acid chain or cholesterol) content on PMs of hydrophobically modified amphiphilic random copolymers directs the most effective delivery system. The ionic (zwitterionic, cationic, and anionic) random copolymers without having any typical hydrophobe in the backbone form more biocompatible pH-sensitive PS, where PEG forms the bilayer. The cationic PSs are able to carry not only drugs, but also transfect genetic materials to the target site. In addition to pH-sensitivity, the anionic PSs can show glutathione-triggered release of encapsulated drug with disintegration of the vesicles. 212 pp. Englisch. Nº de ref. del artículo: 9783330081970

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Partha Laskar
Publicado por LAP Lambert Academic Publishing Mai 2017 (2017)
ISBN 10: 333008197X ISBN 13: 9783330081970
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Descripción LAP Lambert Academic Publishing Mai 2017, 2017. Taschenbuch. Condición: Neu. Neuware - Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of novel stimuli-sensitive self-assembled polymeric micelle (PM) and polymersome (PS) from PEGylated random copolymers as an easy alternative source instead of synthetically more challenging block copolymers. These spontaneously formed stable nanocarriers from easily synthesized random copolymers can not only carry hydrophobic and/or hydrophilic drugs, but also show pH-sensitive release of encapsulated guest. The impact of different hydrophobe (fatty acid chain or cholesterol) content on PMs of hydrophobically modified amphiphilic random copolymers directs the most effective delivery system. The ionic (zwitterionic, cationic, and anionic) random copolymers without having any typical hydrophobe in the backbone form more biocompatible pH-sensitive PS, where PEG forms the bilayer. The cationic PSs are able to carry not only drugs, but also transfect genetic materials to the target site. In addition to pH-sensitivity, the anionic PSs can show glutathione-triggered release of encapsulated drug with disintegration of the vesicles. 212 pp. Englisch. Nº de ref. del artículo: 9783330081970

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Laskar, Partha
Publicado por LAP Lambert Academic Publishing (2017)
ISBN 10: 333008197X ISBN 13: 9783330081970
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Descripción LAP Lambert Academic Publishing, 2017. Kartoniert / Broschiert. Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung für Sie gedruckt. Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of. Nº de ref. del artículo: 151236999

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Partha Laskar
Publicado por LAP Lambert Academic Publishing (2017)
ISBN 10: 333008197X ISBN 13: 9783330081970
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Descripción LAP Lambert Academic Publishing, 2017. Taschenbuch. Condición: Neu. Druck auf Anfrage Neuware - Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of novel stimuli-sensitive self-assembled polymeric micelle (PM) and polymersome (PS) from PEGylated random copolymers as an easy alternative source instead of synthetically more challenging block copolymers. These spontaneously formed stable nanocarriers from easily synthesized random copolymers can not only carry hydrophobic and/or hydrophilic drugs, but also show pH-sensitive release of encapsulated guest. The impact of different hydrophobe (fatty acid chain or cholesterol) content on PMs of hydrophobically modified amphiphilic random copolymers directs the most effective delivery system. The ionic (zwitterionic, cationic, and anionic) random copolymers without having any typical hydrophobe in the backbone form more biocompatible pH-sensitive PS, where PEG forms the bilayer. The cationic PSs are able to carry not only drugs, but also transfect genetic materials to the target site. In addition to pH-sensitivity, the anionic PSs can show glutathione-triggered release of encapsulated drug with disintegration of the vesicles. 212 pp. Englisch. Nº de ref. del artículo: 9783330081970

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