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Descripción Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of novel stimuli-sensitive self-assembled polymeric micelle (PM) and polymersome (PS) from PEGylated random copolymers as an easy alternative source instead of synthetically more challenging block copolymers. These spontaneously formed stable nanocarriers from easily synthesized random copolymers can not only carry hydrophobic and/or hydrophilic drugs, but also show pH-sensitive release of encapsulated guest. The impact of different hydrophobe (fatty acid chain or cholesterol) content on PMs of hydrophobically modified amphiphilic random copolymers directs the most effective delivery system. The ionic (zwitterionic, cationic, and anionic) random copolymers without having any typical hydrophobe in the backbone form more biocompatible pH-sensitive PS, where PEG forms the bilayer. The cationic PSs are able to carry not only drugs, but also transfect genetic materials to the target site. In addition to pH-sensitivity, the anionic PSs can show glutathione-triggered release of encapsulated drug with disintegration of the vesicles. 212 pp. Englisch. Nº de ref. del artículo: 9783330081970
Descripción Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Stimuli-sensitive polymeric nanocarriers are considered to be important colloidal systems for drug and gene delivery. The book describes in vitro evaluation of novel stimuli-sensitive self-assembled polymeric micelle (PM) and polymersome (PS) from PEGylated random copolymers as an easy alternative source instead of synthetically more challenging block copolymers. These spontaneously formed stable nanocarriers from easily synthesized random copolymers can not only carry hydrophobic and/or hydrophilic drugs, but also show pH-sensitive release of encapsulated guest. The impact of different hydrophobe (fatty acid chain or cholesterol) content on PMs of hydrophobically modified amphiphilic random copolymers directs the most effective delivery system. The ionic (zwitterionic, cationic, and anionic) random copolymers without having any typical hydrophobe in the backbone form more biocompatible pH-sensitive PS, where PEG forms the bilayer. The cationic PSs are able to carry not only drugs, but also transfect genetic materials to the target site. In addition to pH-sensitivity, the anionic PSs can show glutathione-triggered release of encapsulated drug with disintegration of the vesicles. Nº de ref. del artículo: 9783330081970
Descripción Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Laskar ParthaPartha Laskar: Research Associate - Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK. He received Ph.D. from the Department of Chemistry, Indian Institute of Technology Khar. Nº de ref. del artículo: 151236999
Descripción Paperback. Condición: Brand New. 212 pages. 8.66x5.91x0.48 inches. In Stock. Nº de ref. del artículo: zk333008197X