Mitosenes and Related Antitumor Drugs: Rational Design and Cytostatic Agents (Medical Intelligence Unit) - Tapa dura

Discusses several aspects of 30 mitosene compounds, focusing on those that are bioreductively activated. They are the synthetic routes used to obtain them, the different types of reductive activation, the effect of external factors on activation, physico-chemical parameters that can affect the antitumor activity, the molecular mechanisms of such activity, pre-clinical testing in in vitro and in vivo tumor models, and full clinical trials. Annotation c. by Book News, Inc., Portland, Or.