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Tumor suppressor gene activity in lung, colon and breast carcinomas: PPP2R1B mechanisms of tumorigenesis and heritable cancer susceptibility (Paperback)

EDWARD ESPLIN

ISBN 10: 3838325001 / ISBN 13: 9783838325002
Editorial: LAP Lambert Acad. Publ., 2010
Nuevos Condición: New Encuadernación de tapa blanda
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Language: English . Brand New Book. The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A? gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A? in many human cancers suggest PP2A-A? is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A? in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A? reducing its ability to bind the PP2A complex. Transfecting the PP2A-A? gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A? are found to have lower levels of ?-catenin, suggesting the PP2A-A? gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A? gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer. N° de ref. de la librería KNV9783838325002

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Título: Tumor suppressor gene activity in lung, ...

Editorial: LAP Lambert Acad. Publ.

Año de publicación: 2010

Encuadernación: Paperback

Condición del libro:New

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The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A? gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A? in many human cancers suggest PP2A-A? is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A? in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A? reducing its ability to bind the PP2A complex. Transfecting the PP2A-A? gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A? are found to have lower levels of ?-catenin, suggesting the PP2A-A? gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A? gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer.

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