Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation

ISBN 10: 384849390X / ISBN 13: 9783848493906
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Sinopsis: The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP?-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP?-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP?-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP?-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.

Biografía del autor: Lokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.He has five years of research experience in controlled and targetted drug delivery.

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Título: Enhancement of complexation of drug: binary ...
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Lokesh Kumar Bhati
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Descripción LAP Lambert Academic Publishing, 2012. PAP. Estado de conservación: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. de la librería LQ-9783848493906

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Bhati, Lokesh Kumar; Bhati, Meena; Tiwari, Gaurav
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Descripción LAP Lambert Academic Publishing, 2012. Estado de conservación: New. This item is printed on demand for shipment within 3 working days. Nº de ref. de la librería KP9783848493906

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Bhati, Lokesh Kumar
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Descripción LAP Lambert Academic Publishing, 2016. Paperback. Estado de conservación: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Nº de ref. de la librería ria9783848493906_lsuk

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Lokesh Kumar Bhati
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Descripción LAP Lambert Academic Publishing, 2012. PAP. Estado de conservación: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. de la librería IQ-9783848493906

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Lokesh Kumar Bhati, Meena Bhati, Gaurav Tiwari
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Descripción LAP Lambert Academic Publishing, Germany, 2012. Paperback. Estado de conservación: New. Aufl.. 220 x 150 mm. Language: English . Brand New Book ***** Print on Demand *****.The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP -CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP -CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP -CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP -CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability. Nº de ref. de la librería AAV9783848493906

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Bhati, Lokesh Kumar; Bhati, Meena; Tiwari, Gaurav
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Descripción LAP LAMBERT Academic Publishing, 2012. Paperback. Estado de conservación: New. This item is printed on demand. Nº de ref. de la librería INGM9783848493906

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Gaurav Tiwari
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Descripción LAP Lambert Academic Publishing. Paperback. Estado de conservación: New. Paperback. 120 pages. Dimensions: 8.7in. x 5.9in. x 0.3in.The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5. 8) exhibited a stability constant 12. 9 times greater than the binary complex. The drug solubility in the presence of 50mM HP-CD was about 6. 23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Nº de ref. de la librería 9783848493906

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