"Sobre este título" puede pertenecer a otra edición de este libro.
Gastos de envío:
EUR 11,81
De Reino Unido a Estados Unidos de America
Descripción Condición: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Nº de ref. del artículo: ria9783838125305_lsuk
Descripción Condición: New. Nº de ref. del artículo: ABLING22Oct2817100592273
Descripción PF. Condición: New. Nº de ref. del artículo: 6666-IUK-9783838125305
Descripción Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drug resistance constitutes a major challenge in the treatment of metastatic neuroendocrine cancer. Chemotherapeutic regimes for these tumours employ weak-base drugs such as etoposide. Especially for this medication, a mechanism of resistance was suggested that linked increased acidification of intracellular compartments to the evolution of drug resistance. So far, most research groups have focused on the role of the driving force behind compartmental acidification, the vacuolar H+-ATPase, in drug resistance. However, chloride channels of the ClC-family also play a pivotal role in the pH homeostasis of cellular organelles, and recently the first evidence for a potential role of ClC-3 in drug resistance was given. Following this finding, this work aims to further elucidate the role of ClC-channels and compartmental acidification in the evolution of etoposide resistance. In this context it focuses on the question of whether an up-regulation of intracellular ClC-channels can be observed as a cellular response to chemotherapeutic drugs and whether it will entail increased compartmental acidity and thus contribute to the evolution of drug resistance in vitro. 60 pp. Englisch. Nº de ref. del artículo: 9783838125305
Descripción PAP. Condición: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. del artículo: L0-9783838125305
Descripción Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Drug resistance constitutes a major challenge in the treatment of metastatic neuroendocrine cancer. Chemotherapeutic regimes for these tumours employ weak-base drugs such as etoposide. Especially for this medication, a mechanism of resistance was suggested that linked increased acidification of intracellular compartments to the evolution of drug resistance. So far, most research groups have focused on the role of the driving force behind compartmental acidification, the vacuolar H+-ATPase, in drug resistance. However, chloride channels of the ClC-family also play a pivotal role in the pH homeostasis of cellular organelles, and recently the first evidence for a potential role of ClC-3 in drug resistance was given. Following this finding, this work aims to further elucidate the role of ClC-channels and compartmental acidification in the evolution of etoposide resistance. In this context it focuses on the question of whether an up-regulation of intracellular ClC-channels can be observed as a cellular response to chemotherapeutic drugs and whether it will entail increased compartmental acidity and thus contribute to the evolution of drug resistance in vitro. Nº de ref. del artículo: 9783838125305
Descripción PAP. Condición: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. del artículo: L0-9783838125305
Descripción Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Rietmann FelixFelix Rietmann, Dr. med., has studied medicine in Berlin,Toulouse and Paris, andHistory of Science, Medicine and Technology in London. He iscurrently working as a paediatrician at the CHUV in Lausanne, Switzerland. His . Nº de ref. del artículo: 5406869