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Functional Selectivity of G Protein-Coupled Receptor Ligands: New Opportunities for Drug Discovery (The Receptors) - Tapa blanda
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“This book presents the current status of knowledge about ligand-specific intracellular signaling. ... This book will be of greatest interest and utility to scientists actively involved in research into G protein-coupled receptors or drug discovery. ... This is a ... thorough, and detailed assessment of the current state of knowledge and recent developments in the field of G protein-coupled receptor function, signaling, and pharmacology.” (Beth Levant, Doody’s Review Service, December, 2009)
“Gives a comprehensive overview on all aspects of the functional selectivity concept of GPCR ligands ... . It will help to generate more awareness for a key topic within the research community. ... the volume at hand is of great educational benefit. ... In general, the volume under review can be considered an excellent book ... . can be an excellent companion for researchers just jumping into the field of GPCR agonist research, as well as for the expert scientist in the field.” (Christoph Boss, ChemMedChem, Vol. 5, 2010)
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In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
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Functional Selectivity of G Protein-Coupled Receptor Ligands : New Opportunities for Drug Discovery
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Functional Selectivity of G Protein-Coupled Receptor Ligands
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Humana Press Aug 2016, 2016
ISBN 10: 1493961160
ISBN 13: 9781493961160
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Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function. 304 pp. Englisch. Nº de ref. del artículo: 9781493961160
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Functional Selectivity of G Protein-Coupled Receptor Ligands: New Opportunities for Drug Discovery (The Receptors)
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Functional Selectivity of G Protein-Coupled Receptor Ligands: New Opportunities for Drug Discovery (The Receptors) [Paperback ]
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Functional Selectivity of G Protein-Coupled Receptor Ligands
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Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at path. Nº de ref. del artículo: 447957083
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Functional Selectivity of G Protein-Coupled Receptor Ligands : New Opportunities for Drug Discovery
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Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function. Nº de ref. del artículo: 9781493961160
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