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Sinopsis
TRANSLATIONAL RESEARCH AND DISCOVERY IN GASTROENTEROLOGY: ORGANOGENESIS TO DISEASE BRIDGES THE GAP BETWEEN BASIC AND CLINICAL RESEARCH BY PROVIDING BASIC SCIENCE INFORMATION ON GI ORGAN DEVELOPMENT SIDE BY SIDE WITH CLINICAL OBSERVATIONS OF ACQUIRED AND CONGENITAL ABNORMALITIES. INDIVIDUAL CHAPTERS REVIEW THE ORGANOGENESIS OF EACH ORGAN OF THE GASTROINTESTINAL TUBE - ESOPHAGUS, STOMACH, PYLORUS, SMALL INTESTINE, AND COLON - EXAMINING THE MAJOR BIOLOGICAL PATHWAYS AND MOLECULES AT WORK IN ORGAN ONTOGENY, AS WELL AS THE MODEL SYSTEMS AVAILABLE FOR STUDY OF THAT ORGAN. IN A PAIRED CHAPTER, DISEASES AND ABNORMALTIES OF THE SAME ORGAN ARE DISCUSSED AND, WHERE POSSIBLE, TIED TO KNOWN PATHWAYS. IN ADDITION TO A COMPREHENSIVE SURVEY OF GI ORGAN DEVELOPMENT AND PATHOLOGIES, THE BOOK ALSO HIGHLIGHTS NEW IMPORTANT AREAS OF RESEARCH, WITH CHAPTERS DEVOTED TO RECENT ADVANCES IN THE FIELD OF GASTROINTESTINAL STEM CELL BIOLOGY, AND THE POTENTIAL FOR TISSUE ENGINEERING OF GASTROINTESTINAL ORGANS. AS INTEREST IN AND FUNDING FOR GI DEVELOPMENT RESEARCH GROWS, TRANSLATIONAL RESEARCH AND DISCOVERY IN GASTROENTEROLOGY PROVIDES A UNIQUE WINDOW ONTO CURRENT ACTIVITY IN THE FIELD BY BRINGING TOGETHER BASIC AND CLINICAL SCIENCE IN NEW AND SYNERGISTIC WAYS, FOSTERING ENHANCED KNOWLEDGE FOR DEVELOPMENTAL BIOLOGISTS AS WELL AS CLINICAL PRACTITIONERS IN THE FIELD OF GASTROENTEROLOGY.
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Reseña del editor
Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. Derivative organs esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. Chapters detailing the use of model organisms Drosophila, sea urchin, zebrafish, C. elegans, Xenopus for basic discovery studies are included. Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.
Biografía del autor
Deborah L. Gumucio, PhD, is the James Douglas Engel Professor and Interim Chair of the Department of Cell and Developmental Biology at the University of Michigan Medical School and Project Director of the University of Michigan s BioArtography Program. Linda C. Samuelson, PhD, is the John A. Williams Collegiate Professor of Gastrointestinal Physiology and Professor in the Departments of Molecular and Integrative Physiology and Internal Medicine at the University of Michigan Medical School and serves as Associate Director for the Center for Organogenesis at the University of Michigan. Jason R. Spence, PhD, is Assistant Professor of Internal Medicine and Assistant Professor of Cell and Developmental Biology at the University of Michigan Medical School.
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- EditorialWiley-Blackwell
- Año de publicación2014
- ISBN 10 1118492870
- ISBN 13 9781118492871
- EncuadernaciónTapa dura
- Número de páginas352
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Hardcover. Condición: NEW. Hardcover. Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. Derivative organs esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. Chapters detailing the use of model organisms Drosophila, sea urchin, zebrafish, C. elegans, Xenopus for basic discovery studies are included. Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs. Bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Nº de ref. del artículo: 9781118492871
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