Combinatorial Synthesis of Natural Product-Based Libraries (Critical Reviews in Combinatorial Chemistry)

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9780849340000: Combinatorial Synthesis of Natural Product-Based Libraries (Critical Reviews in Combinatorial Chemistry)

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery.

The book details the latest approaches for implementing combinatorial research and testing methodologies to the synthesis of natural product-based libraries. Interconnecting the important aspects of this emerging field through the work of several leading scientists, it covers the computational analysis of natural molecules and details strategies for designing compound libraries, using bioinformatics in particular. The authors describe numerous synthetic methods for producing natural products and their analogs, including engineered biosynthesis and polymer-supported reagents. They also discuss additional considerations for generating libraries, such as screening, scaffolding, and yield optimization. Other chapters examine specific classes of libraries derived from natural products including carbohydrates, polyketides, peptides, alkaloids, terpenoids, steroids, flavonoids, and fungal compounds.

Drawing attention to the interplay of drug discovery, natural products, and organic synthesis, Combinatorial Synthesis of Natural Product-Based Libraries contains the most recent and significant methods used to search and assess new compounds for their ability to mitigate biological processes that may lead to improved treatments for various diseases.

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[This book] elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the historical developments to the latest technologies, from the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ...A huge amount of references give the readers the opportunity to return to the original papers... ... A large amount of appealing Figures and Schemes illustrate the concepts discussed in the text. The Chapters are well structured... As the authors are from different backgrounds, the book covers various strategies, various synthetic methods, and all types of compound families. ...[A] valuable tool for everybody working in medicinal chemistry as well as the agrochemical, industrial, or academic domains.
- François Diederich, Swiss Federal Institute of Technology, Zurich

...Elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ...
- François Diederich, Swiss Federal Institute of Technology, Zurich

A first-rate source of information to learn about different planning strategies
-Victor E. Marquez in Journal of Medicinal Chemistry 2007, Vol. 50, No. 5 (2007)

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Editorial: CRC Press (2006)
ISBN 10: 0849340004 ISBN 13: 9780849340000
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Descripción CRC Press, 2006. Hardcover. Estado de conservación: New. book. Nº de ref. de la librería 0849340004

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Editorial: Taylor Francis Inc, United States (2006)
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Descripción Taylor Francis Inc, United States, 2006. Hardback. Estado de conservación: New. Language: English . Brand New Book. Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery. The book details the latest approaches for implementing combinatorial research and testing methodologies to the synthesis of natural product-based libraries. Interconnecting the important aspects of this emerging field through the work of several leading scientists, it covers the computational analysis of natural molecules and details strategies for designing compound libraries, using bioinformatics in particular. The authors describe numerous synthetic methods for producing natural products and their analogs, including engineered biosynthesis and polymer-supported reagents. They also discuss additional considerations for generating libraries, such as screening, scaffolding, and yield optimization. Other chapters examine specific classes of libraries derived from natural products including carbohydrates, polyketides, peptides, alkaloids, terpenoids, steroids, flavonoids, and fungal compounds. Drawing attention to the interplay of drug discovery, natural products, and organic synthesis, Combinatorial Synthesis of Natural Product-Based Libraries contains the most recent and significant methods used to search and assess new compounds for their ability to mitigate biological processes that may lead to improved treatments for various diseases. Nº de ref. de la librería AA69780849340000

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Editorial: Taylor Francis Inc, United States (2006)
ISBN 10: 0849340004 ISBN 13: 9780849340000
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Descripción Taylor Francis Inc, United States, 2006. Hardback. Estado de conservación: New. Language: English . Brand New Book. Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery. The book details the latest approaches for implementing combinatorial research and testing methodologies to the synthesis of natural product-based libraries. Interconnecting the important aspects of this emerging field through the work of several leading scientists, it covers the computational analysis of natural molecules and details strategies for designing compound libraries, using bioinformatics in particular. The authors describe numerous synthetic methods for producing natural products and their analogs, including engineered biosynthesis and polymer-supported reagents.They also discuss additional considerations for generating libraries, such as screening, scaffolding, and yield optimization. Other chapters examine specific classes of libraries derived from natural products including carbohydrates, polyketides, peptides, alkaloids, terpenoids, steroids, flavonoids, and fungal compounds. Drawing attention to the interplay of drug discovery, natural products, and organic synthesis, Combinatorial Synthesis of Natural Product-Based Libraries contains the most recent and significant methods used to search and assess new compounds for their ability to mitigate biological processes that may lead to improved treatments for various diseases. Nº de ref. de la librería AA69780849340000

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Armen M. Boldi
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Descripción CRC Press, 2006. HRD. Estado de conservación: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Nº de ref. de la librería FT-9780849340000

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Descripción Estado de conservación: New. Depending on your location, this item may ship from the US or UK. Nº de ref. de la librería 97808493400000000000

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Descripción CRC Press, 2006. Hardcover. Estado de conservación: New. 1. Nº de ref. de la librería DADAX0849340004

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Editorial: Taylor & Francis Inc 2006-05-16, Bosa Roca (2006)
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Descripción Taylor & Francis Inc 2006-05-16, Bosa Roca, 2006. hardback. Estado de conservación: New. Nº de ref. de la librería 9780849340000

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Descripción Taylor & Francis Inc. Hardback. Estado de conservación: new. BRAND NEW, Combinatorial Synthesis of Natural Product-Based Libraries, Armen M. Boldi, Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery. The book details the latest approaches for implementing combinatorial research and testing methodologies to the synthesis of natural product-based libraries. Interconnecting the important aspects of this emerging field through the work of several leading scientists, it covers the computational analysis of natural molecules and details strategies for designing compound libraries, using bioinformatics in particular. The authors describe numerous synthetic methods for producing natural products and their analogs, including engineered biosynthesis and polymer-supported reagents. They also discuss additional considerations for generating libraries, such as screening, scaffolding, and yield optimization. Other chapters examine specific classes of libraries derived from natural products including carbohydrates, polyketides, peptides, alkaloids, terpenoids, steroids, flavonoids, and fungal compounds. Drawing attention to the interplay of drug discovery, natural products, and organic synthesis, Combinatorial Synthesis of Natural Product-Based Libraries contains the most recent and significant methods used to search and assess new compounds for their ability to mitigate biological processes that may lead to improved treatments for various diseases. Nº de ref. de la librería B9780849340000

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Descripción 2006. HRD. Estado de conservación: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Nº de ref. de la librería VT-9780849340000

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