Handbook on Syntheses of Amino Acids: General Routes to Amino Acids (An American Chemical Society Publication) - Tapa dura

"A useful reference work, particularly for the peptide and medicinal chemistry communities. Though a voluminous work, the well-organized and detailed Table of Contents will allow the reader to home in on the class of amino acid that he or she seeks and expeditiously capture the range of reaction modality available to access these targets. As such, active practitioners of the art of peptide or peptidomimetic construct design, sythesis, and study will likely benefit from having this volume on a nearby shelf."--The Journal of the American Chemcial Society "A useful reference work, particularly for the peptide and medicinal chemistry communities. Though a voluminous work, the well-organized and detailed Table of Contents will allow the reader to home in on the class of amino acid that he or she seeks and expeditiously capture the range of reaction modality available to access these targets. As such, active practitioners of the art of peptide or peptidomimetic construct design, sythesis, and study will likely benefit from having this volume on a nearby shelf."--The Journal of the American Chemcial Society

Amino acid synthesis is a field of research that has existed for over 150 years, but renewed interest has led to an exponential increase in publications in the past two decades. The Handbook on Syntheses of Amino Acids provides a comprehensive survey of synthetic procedures that prepare natural and unnatural amino acids in both racemic and optically active forms. The book begins with an introduction to amino acids, their properties, and anylytical techniques, including a detailed examination of methods used to establish enantiomeric configuration and optical purity. The next two chapters focus on processes for preparing racemic amino acids, dividing into those syntheses that introduce the amino and/or carboxy groups, and those that introduce the side chain. While some of these procedures date from the 1800s, modified versions are still extensively employed. A key component of these chapters is tables that summarize that summarize the many compounds made by each method. A chapter devoted to 2, 3-dehydroamino acids provides the bridge between racemic and asymmetric syntheses, as dehydroamino acids are themselvces achiral, but can be transformed into optically active products. Asymmetric amino acid preparations are then divided into six chapters, based on methods that introduce the amino and/or carboxy groups, those that introduce the side chains to acyclic synthons, those that introduce side chain to cyclic templates, those that open small ring systems, and those that derive the amino acided from other amino acids (with a separate chapter for serine-derived products). The growing field of non-?-amino acid synthesis is adressed in a separate chapter . The book is completed by a discussion of amino acids, including resolutions, N-alkylations, amidations and peptide couplings.