Cellular trans-membrane signalling mechanisms are among the most highly studied processes in the biological sciences. G-proteins provide transduction components to allow communication between receptors for hormones and neurotransmitters and their effector systems which include enzymes involved in the generation of intracellular secondary messengers and a variety of ion channels. Signal Transduction: A Practical Approach details the experimental approaches which are used to define the contacts between receptors and G-proteins and between these G-proteins and their effector systems. While much emphasis in the cellular signalling field remains on the measurement of adenylyl cyclase and of phosphoinositidase C activities, it is now clear that activation of G-protein linked receptors can also cause the regulation of phospholipases of the D and A2 classes. Thus, assays used to measure the activities of these enzyme systems are detailed in this book. The use of mutagenesis to define functional domains of G-proteins themselves has undergone considerable progress recently and examples of this approach are also included. This volume provides a useful guide to the newcomer to the subject, as well as allowing workers already in the field to expand the range of approaches in use in their laboratories.
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G. Milligan, Department of Biochemistry, University of Glasgow.Review:
'This volume provides a useful guide ... As is usual in this series, protocols are set out in some detail with full discussion of practical difficulties and limitations, and the book can be used by both newcomers to the field and experienced laboratory workers.'
Aslib Book Guide, Vol. 58, No. 1, January 1993
'an extremely useful addition to the collection of anyone interested in studying signal transduction ... ideal for researchers new to the area or researchers wishing to expand the range of intracellular messengers investigated in their laboratory'
Cardiovascular Research, April 1994
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Descripción Oxford University Press, 1992. Broschiert. Estado de conservación: Gut. 185 Seiten Der Erhaltungszustand des hier angebotenen Werks ist trotz seiner Bibliotheksnutzung sehr sauber. Es befindet sich lediglich ein Bibliotheksstempel im Buch; ordnungsgemäß entwidmet. Sprache: Englisch Gewicht in Gramm: 360. Nº de ref. de la librería 1368388
Descripción Oxford: IRL Press, 1992. Softcover/Paperback. 185 pages. Good. Ex-library with usual library markings. Clean pages. Sprache: Englisch Gewicht in Gramm: 440. Nº de ref. de la librería 65629
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Descripción -. Paperback. Estado de conservación: Very Good. Signal Transduction: A Practical Approach This book is in very good condition and will be shipped within 24 hours of ordering. The cover may have some limited signs of wear but the pages are clean, intact and the spine remains undamaged. This book has clearly been well maintained and looked after thus far. Money back guarantee if you are not satisfied. See all our books here, order more than 1 book and get discounted shipping. Nº de ref. de la librería 7719-9780199632954
Descripción IrL Press at Oxford University Press., Oxford, New York, Tokyo., 1992. OBroschur. XX, 185S. Namensstempel auf Vortitelblatt, abgesehen hiervon guter Zustand. Size: 8°. Nº de ref. de la librería 033810
Descripción Irl Pr, McLean, Virginia, U.S.A., 1992. Soft Cover. Estado de conservación: Fine. 1st Printing. Clean copy in fine condition. Size: 8vo - over 7¾" - 9¾" tall. Nº de ref. de la librería 016251
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