This combination of theory and application is unusual and broadens the appeal of the book for researchers or for teachers of advanced seminars...This gives the book a light and readable quality ( Mark Pagel The Quarterly Review of Biology)From the Publisher:
Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields.
Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including whole proteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized to provide insights and inform future research.
This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.
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Descripción Oup. Estado de conservación: New. Original Books from across the World in Brand New Condition --------- It can be shipped from U.S, Canada, Germany & India/Overseas centre subject to availability.,9780199299188. book. Nº de ref. de la librería SI-2016-1265
Descripción OUP Oxford, 2007. Hardcover. Estado de conservación: New. New, mint condition. Orders are despatched from our UK warehouse next working day. Nº de ref. de la librería 62419
Descripción Oxford University Press, 2007. Estado de conservación: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: 1. The Early Days of Paleogenomics, Connecting Molecules to the Planet, Steven A. Benner 2. Ancestral Sequence Reconstruction as a Tool to Understand Natural History and Guide Synthetic Biology: Realizing and Extending the Vision of Zuckerkandl and Pauling, Eric A. Gaucher 3. Linking Sequence to Function in Drug Design with Ancestral Sequence Reconstruction, Janos T. Kodra, Marie Skovgaard, Dennis Madsen, and David A. Liberles 4. Probabilistic Models and Their Impact on the Accuracy of Reconstructed Ancestral Sequences, Tal Pupko, Adi Doron-Faigenboim, David A. Liberles, and Gina M. Cannarozzi 5. Probabilistic Ancestral Sequences Based on the Markovian Model of Evolution- Algorithms and Applications, Gina M. Cannarozzi, Adrian Schneider, and Gaston H. Gonnet 6. Estimating the History of Mutations on a Phylogeny, Jonathan P. Bollback, Paul P. Gardner, and Rasmus Nielsen 7. Coarse Projections of the Protein-Mutational Fitness Landscape, F. Nicholas Braun 8. Dealing with Uncertainty in Ancestral Sequence Reconstruction: Sampling from the Posterior Distribution, David D. Pollock and Belinda S. W. Chang 9. Evolutionary Properties of Sequences and Ancestral State Reconstruction, Lesley J. Collins and Peter J. Lockhart 10. Reconstructing the Ancestral Eukaryote- Lessons from the Past, Mary J. O'Connell and James O. McInerney 11. Using Ancestral Sequence Inference to Determine the Trend of Functional Divergence After Gene Duplication, Xun Gu, Ying Zheng, Yong Huang, and Dongping Xu 12. Reconstruction of Ancestral Proteomes, Toni Gabaldon and Martijn A. Huynen 13. Computational Reconstruction of Ancestral Genomic Regions from Evolutionarily Conserved Gene Clusters, Etienne G. J. Danchin, Eric A. Gaucher, and Pierre Pontarotti 14. Experimental Resurrection of Ancient Biomolecules: Gene Synthesis, Heterologous Protein Expression, and Functional Assays, Eric A. Gaucher 15. Dealing with Model Uncertainty in Reconstructing Ancestral Proteins in the Laboratory: Examples from Ancestral Visual Pigments and GFP-like Proteins, Belinda S. W. Chang, Mikhail V. Matz, Steven F. Field, Johannes Muller, and Ilke van Hazel 16. Unraveling the Evolution of Complexity by Resurrecting Ancient Genes, Joseph W. Thornton and Jamie T. Bridgham 17. A Thermophilic Last Universal Ancestor Inferred from its Estimated Amino Acid Composition, Dawn J. Brooks and Eric A. Gaucher 18. The Resurrection of Ribonucleases from Mammals. From Ecology to Medicine, Slim O. Sassi and Steven A. Benner 19. Evolution of Specificity and Diversity, Denis C. Shields, Kate Johnston, Iain M. Wallace, and Richard J. Edwards. Nº de ref. de la librería ABE_book_new_0199299188
Descripción Oxford University Press, 2007. Hardcover. Estado de conservación: New. book. Nº de ref. de la librería 0199299188
Descripción Oxford University Press, 2007. Hardcover. Estado de conservación: New. Nº de ref. de la librería P110199299188
Descripción Oxford University Press, USA, 2007. Hardcover. Estado de conservación: New. Nº de ref. de la librería SONG0199299188
Descripción Oxford University Press. Estado de conservación: New. pp. 272. Nº de ref. de la librería 5265667
Descripción Estado de conservación: Brand New. Book Condition: Brand New. Nº de ref. de la librería 97801992991881.0