This book describes statistical concepts and techniques for evaluating medical diagnostic tests and biomarkers for detecting disease. More generally, the techniques pertain to the statistical classification problem for predicting a dichotomous outcome. Measures for quantifying test accuracy are described including sensitivity, specificity, predictive values, diagnostic likelihood ratios and the Receiver Operating Characteristic Curve that is commonly used for continuous and ordinal valued tests. Statistical procedures are presented for estimating and comparing them. Regression frameworks for assessing factors that influence test accuracy and for comparing tests while adjusting for such factors are presented. This book presents many worked examples of real data and should be of interest to practicing statisticians or quantitative researchers involved in the development of tests for classification or prediction in medicine.
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Margaret Sullivan Pepe is a Professor of Biostatistics, University of Washington and Fred Hutchinson Cancer Research Center, Washington, USA.Review:
I very much recommend this book to a range of audiences, from those wanting an introduction to diagnostic test concepts and methods to active researchers in the area. This book is likely to stimulate considerable progress in development of new statistical methods for diagnostic tests, an area that relative to therapeutics has received little attention from biostatisticians. * Journal of Biopharmaceutical Studies * Statistical results are given a methodical treatment. In each chapter statistical results are motivated, stated and usually proven, and then illustrated on a variety of datasets based on actual trials. Many of the results were developed by Pepe and her colleagues, who have advanced the field in seminal ways. Chapters end with a concluding remarks section, a set of exercises, and proofs of more involved theoretical results, when needed. Concluding remarks sections nicely summarize results and discuss open research questions. References to key papers are given throughout. This structure allows the book to serve as both a classroom text and an excellent reference to the current literature. * Journal of Biopharmaceutical Studies * It is a clear and authorative work which will be invaluable for anyone trying to establish a new diagnostic test. * Derek Robinson, University of Sussex, Brighton *
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Descripción U.S.A.: Oxford University Press, 2003. Hardcover. Estado de conservación: New. 1st Edition. NEW. Nº de ref. de la librería 0198509847
Descripción Oxford University Press, 2003. Hardcover. Estado de conservación: New. Nº de ref. de la librería P110198509847
Descripción Oxford Univ Pr, 2003. Hardcover. Estado de conservación: Brand New. 1st edition. 320 pages. 9.00x6.00x0.75 inches. In Stock. Nº de ref. de la librería __0198509847
Descripción Oxford University Press, USA, 2003. Hardcover. Estado de conservación: New. 1. Nº de ref. de la librería DADAX0198509847