Gene Regulation : A Eukaryotic Perspective - Tapa dura

"Gene Regulation" provides a view of gene control systems from a eukaryotic standpoint, and tries to redress the bias towards prokaryotic control models. The text explores a variety of regulational strategies and defines their functional significance to the organism as a whole. The opening chapters examine the possible processes and mechanisms by which genes could be controlled at different levels, and establish that the key control structures lie at the level of gene transciption. Further chapters continue with an examination of the various steps in transcriptional regulation and explain how events at the molecular level finally have their impact on the biology of the organism via the expression of a diversity of proteins. The final section takes a look at the role of malregulation of gene expression in causing human diseases, particularly in relation to certain forms of cancer. This book should appeal to a wide range of intermediate and advanced students of molecular biology, biochemistry, genetics and clinicians working in these areas.