PECTIN HYDROGEL COPOLYMERS FOR SUSTAINED DRUG RELEASE

 
9783843369923: PECTIN HYDROGEL COPOLYMERS FOR SUSTAINED DRUG RELEASE
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The present work describes preparation, optimization and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable theophylline drug release. The gels were prepared in the presence of N,N'-methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. In vitro controllable release of theophylline model drug was studied using different [NVP]/[MBAA] ratios, different [NIPAAm]/[MBAA] ratios and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, for pectin-g-PVP were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10 °C and %G = 62.2. While for pectin- g-PNIPAAm were as follows: [NIPAAm]/[MBAA] = 47.34, polymerization temperature = 10 °C and %G = 50.5. Such promising hydrogel characteristics may play the key role in many future drug release implementations.

Biografía del autor:

Yousef Abul-Haija graduated from Jordan Univ. of Sci. & Tech. as a BSc in Applied Chemistry in 2006. He worked towards MSc under the guidance of Dr. Mohammad Fares and Dr. Shereen Assaf. Directly after his graduation, Yousef worked with Hikma Pharmaceuticals Company.

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Abul-Haija, Yousef
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ISBN 10: 3843369925 ISBN 13: 9783843369923
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Abul-Haija, Yousef
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Abul-Haija, Yousef
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Yousef Abul-Haija
Publicado por LAP Lambert Acad. Publ. Nov 2010 (2010)
ISBN 10: 3843369925 ISBN 13: 9783843369923
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Descripción LAP Lambert Acad. Publ. Nov 2010, 2010. Taschenbuch. Condición: Neu. Neuware - The present work describes preparation, optimization and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable theophylline drug release. The gels were prepared in the presence of N,N' methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. In vitro controllable release of theophylline model drug was studied using different [NVP]/[MBAA] ratios, different [NIPAAm]/[MBAA] ratios and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, for pectin-g-PVP were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10 °C and %G = 62.2. While for pectin- g-PNIPAAm were as follows: [NIPAAm]/[MBAA] = 47.34, polymerization temperature = 10 °C and %G = 50.5. Such promising hydrogel characteristics may play the key role in many future drug release implementations. 76 pp. Englisch. Nº de ref. del artículo: 9783843369923

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Yousef Abul-Haija
Publicado por LAP Lambert Acad. Publ. Nov 2010 (2010)
ISBN 10: 3843369925 ISBN 13: 9783843369923
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Descripción LAP Lambert Acad. Publ. Nov 2010, 2010. Taschenbuch. Condición: Neu. Neuware - The present work describes preparation, optimization and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable theophylline drug release. The gels were prepared in the presence of N,N' methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. In vitro controllable release of theophylline model drug was studied using different [NVP]/[MBAA] ratios, different [NIPAAm]/[MBAA] ratios and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, for pectin-g-PVP were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10 °C and %G = 62.2. While for pectin- g-PNIPAAm were as follows: [NIPAAm]/[MBAA] = 47.34, polymerization temperature = 10 °C and %G = 50.5. Such promising hydrogel characteristics may play the key role in many future drug release implementations. 76 pp. Englisch. Nº de ref. del artículo: 9783843369923

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Yousef Abul-Haija
Publicado por LAP Lambert Academic Publishing, Germany (2010)
ISBN 10: 3843369925 ISBN 13: 9783843369923
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Descripción LAP Lambert Academic Publishing, Germany, 2010. Paperback. Condición: New. Language: English. Brand new Book. The present work describes preparation, optimization and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable theophylline drug release. The gels were prepared in the presence of N, N'-methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. In vitro controllable release of theophylline model drug was studied using different [NVP]/[MBAA] ratios, different [NIPAAm]/[MBAA] ratios and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, for pectin-g-PVP were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10 C and %G = 62.2. While for pectin- g-PNIPAAm were as follows: [NIPAAm]/[MBAA] = 47.34, polymerization temperature = 10 C and %G = 50.5. Such promising hydrogel characteristics may play the key role in many future drug release implementations. Nº de ref. del artículo: KNV9783843369923

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Yousef Abul-Haija
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ISBN 10: 3843369925 ISBN 13: 9783843369923
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Yousef Abul-Haija
Publicado por LAP Lambert Acad. Publ. Nov 2010 (2010)
ISBN 10: 3843369925 ISBN 13: 9783843369923
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Descripción LAP Lambert Acad. Publ. Nov 2010, 2010. Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Neuware - The present work describes preparation, optimization and characterization of pectin grafted poly (vinylpyrrolidone) hydrogels and pectin grafted poly (N-isopropylacrylamide) followed by controllable theophylline drug release. The gels were prepared in the presence of N,N' methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. In vitro controllable release of theophylline model drug was studied using different [NVP]/[MBAA] ratios, different [NIPAAm]/[MBAA] ratios and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, for pectin-g-PVP were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10 °C and %G = 62.2. While for pectin- g-PNIPAAm were as follows: [NIPAAm]/[MBAA] = 47.34, polymerization temperature = 10 °C and %G = 50.5. Such promising hydrogel characteristics may play the key role in many future drug release implementations. 76 pp. Englisch. Nº de ref. del artículo: 9783843369923

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