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Descripción Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A in many human cancers suggest PP2A-A is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A reducing its ability to bind the PP2A complex. Transfecting the PP2A-A gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A are found to have lower levels of -catenin, suggesting the PP2A-A gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer. 80 pp. Englisch. Nº de ref. del artículo: 9783838325002
Descripción Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A in many human cancers suggest PP2A-A is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A reducing its ability to bind the PP2A complex. Transfecting the PP2A-A gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A are found to have lower levels of -catenin, suggesting the PP2A-A gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer. Nº de ref. del artículo: 9783838325002
Descripción Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: ESPLIN EDWARDThe son of Helen and D. Glen Esplin, married to his lovely wife Michal. A.A. at Dixie College, B.A. Biology and German at University of Utah, served a mission for the Church of Jesus Christ of Latter-day Saints in Zueri. Nº de ref. del artículo: 5413146
Descripción Paperback. Condición: Brand New. 80 pages. 8.66x5.91x0.19 inches. In Stock. Nº de ref. del artículo: zk3838325001