Synthesis & pharmacological evaluation of novel hydrazone derivatives

 
9783330028050: Synthesis & pharmacological evaluation of novel hydrazone derivatives
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Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. These compounds have interesting biological properties, such as antiinflammatory, analgesic, anticonvulsant, antituberculous, antitumor, anti-HIV and antimicrobial activity. Hydrazones are important compounds for drug design, as possible ligands for metal complexes, organocatalysis and also for the synthesis of heterocyclic compounds. Preparation, increased hydrolytic stability relative to imines, and tendency toward crystallinity are all desirable characteristics of hydrazones. Due to these positive traits, hydrazones have been under study for a long time, but much of their basic chemistry remains unexplored. Hydrazones contain two connected nitrogen atoms of different nature and a C-N double bond that is conjugated with alone electron pair of the terminal nitrogen atom. These structural fragments are mainly responsible for the physical and chemical properties of hydrazones. Both nitrogen atoms of the hydrazone group are nucleophilic, although the amino type nitrogen is more reactive. The carbon atom of hydrazone group has both electrophilic and nucleophilic

Biografía del autor:

Vinit Raj (M.Pharm, Ph.D*)Department of Pharmaceutical sciences,Babasaheb Bhimrao Ambedkar University, Lucknow, India.Praveen KumarSD College of Pharmacy and Vocational studies.Dr. Arvind Kumar (M.Pharm, Ph.D)SD College of Pharmacy and Vocational studies,Muzaffarnagar, UP, India

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Vinit Raj
Publicado por LAP Lambert Academic Publishing Jan 2017 (2017)
ISBN 10: 333002805X ISBN 13: 9783330028050
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Descripción LAP Lambert Academic Publishing Jan 2017, 2017. Taschenbuch. Condición: Neu. Neuware - Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. These compounds have interesting biological properties, such as antiinflammatory, analgesic, anticonvulsant, antituberculous, antitumor, anti-HIV and antimicrobial activity. Hydrazones are important compounds for drug design, as possible ligands for metal complexes, organocatalysis and also for the synthesis of heterocyclic compounds. Preparation, increased hydrolytic stability relative to imines, and tendency toward crystallinity are all desirable characteristics of hydrazones. Due to these positive traits, hydrazones have been under study for a long time, but much of their basic chemistry remains unexplored. Hydrazones contain two connected nitrogen atoms of different nature and a C-N double bond that is conjugated with alone electron pair of the terminal nitrogen atom. These structural fragments are mainly responsible for the physical and chemical properties of hydrazones. Both nitrogen atoms of the hydrazone group are nucleophilic, although the amino type nitrogen is more reactive. The carbon atom of hydrazone group has both electrophilic and nucleophilic 100 pp. Englisch. Nº de ref. del artículo: 9783330028050

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Vinit Raj
Publicado por LAP Lambert Academic Publishing Jan 2017 (2017)
ISBN 10: 333002805X ISBN 13: 9783330028050
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Descripción LAP Lambert Academic Publishing Jan 2017, 2017. Taschenbuch. Condición: Neu. Neuware - Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. These compounds have interesting biological properties, such as antiinflammatory, analgesic, anticonvulsant, antituberculous, antitumor, anti-HIV and antimicrobial activity. Hydrazones are important compounds for drug design, as possible ligands for metal complexes, organocatalysis and also for the synthesis of heterocyclic compounds. Preparation, increased hydrolytic stability relative to imines, and tendency toward crystallinity are all desirable characteristics of hydrazones. Due to these positive traits, hydrazones have been under study for a long time, but much of their basic chemistry remains unexplored. Hydrazones contain two connected nitrogen atoms of different nature and a C-N double bond that is conjugated with alone electron pair of the terminal nitrogen atom. These structural fragments are mainly responsible for the physical and chemical properties of hydrazones. Both nitrogen atoms of the hydrazone group are nucleophilic, although the amino type nitrogen is more reactive. The carbon atom of hydrazone group has both electrophilic and nucleophilic 100 pp. Englisch. Nº de ref. del artículo: 9783330028050

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Vinit Raj, Praveen Kumar, ARVIND KUMAR
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ISBN 10: 333002805X ISBN 13: 9783330028050
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Descripción LAP Lambert Academic Publishing, 2017. Paperback. Condición: New. Aufl. Language: English . Brand New Book. Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. These compounds have interesting biological properties, such as antiinflammatory, analgesic, anticonvulsant, antituberculous, antitumor, anti-HIV and antimicrobial activity. Hydrazones are important compounds for drug design, as possible ligands for metal complexes, organocatalysis and also for the synthesis of heterocyclic compounds. Preparation, increased hydrolytic stability relative to imines, and tendency toward crystallinity are all desirable characteristics of hydrazones. Due to these positive traits, hydrazones have been under study for a long time, but much of their basic chemistry remains unexplored. Hydrazones contain two connected nitrogen atoms of different nature and a C-N double bond that is conjugated with alone electron pair of the terminal nitrogen atom. These structural fragments are mainly responsible for the physical and chemical properties of hydrazones. Both nitrogen atoms of the hydrazone group are nucleophilic, although the amino type nitrogen is more reactive. The carbon atom of hydrazone group has both electrophilic and nucleophilic. Nº de ref. del artículo: KNV9783330028050

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Vinit Raj
Publicado por LAP Lambert Academic Publishing Jan 2017 (2017)
ISBN 10: 333002805X ISBN 13: 9783330028050
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Descripción LAP Lambert Academic Publishing Jan 2017, 2017. Taschenbuch. Condición: Neu. This item is printed on demand - Print on Demand Neuware - Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. These compounds have interesting biological properties, such as antiinflammatory, analgesic, anticonvulsant, antituberculous, antitumor, anti-HIV and antimicrobial activity. Hydrazones are important compounds for drug design, as possible ligands for metal complexes, organocatalysis and also for the synthesis of heterocyclic compounds. Preparation, increased hydrolytic stability relative to imines, and tendency toward crystallinity are all desirable characteristics of hydrazones. Due to these positive traits, hydrazones have been under study for a long time, but much of their basic chemistry remains unexplored. Hydrazones contain two connected nitrogen atoms of different nature and a C-N double bond that is conjugated with alone electron pair of the terminal nitrogen atom. These structural fragments are mainly responsible for the physical and chemical properties of hydrazones. Both nitrogen atoms of the hydrazone group are nucleophilic, although the amino type nitrogen is more reactive. The carbon atom of hydrazone group has both electrophilic and nucleophilic 100 pp. Englisch. Nº de ref. del artículo: 9783330028050

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