"On Certain Problems in the Physiology of the Blood Corpuscles." Cartwright Lectures. Delivered before the Association of the Alumni of the College of Physicians and Surgeons, New York, March 23d, 27th, and 30th, 1886. Reprinted from The Medical News, April 3, 10, 17, 1886.

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55 pp, with 24 text figures in all. Original wrappers. Wrappers soiled (much of the soiling is erasable, but I will leave it to you to erase). Very Good. First Edition. The three lectures are: I. The Blood-plaque or Third Corpuscle; II. Degeneration and Regeneration of the Corpuscles; III. The Relation of the Corpuscles to Coagulation and Thrombosis. Originally published in The Medical News, Vol. 48, 1886, pp. 365-370 (with 6 text figures), 393-399 (with 11 text figures), 421-424 (with 7 text figures). "These important lectures, based on original research, begun in 1882 on the blood-plates of Bizzozero (haematoblasts of Hayem), established Osler's reputation as an original investigator. The aggregation of blood platelets which takes place as soon as the blood is withdrawn from the body is known as 'Osler's phenomenon'. In his own words here published: 'I was the first to observe, in 1881, that in the most superficial part of the white thrombi, the blood-plaques were present' " (Golden & Roland 22, reproducing the title page in figure 6 on p. 6, "This research established Osler's reputation as an original investigator"). Garrison-Morton 13281. "The Cartwright Lectures were the last of Osler's experimental observations on platelets. . . . William Osler made some of the earliest key observations that identified platelets as a normal component of blood and linked their function with thrombus formation. Although Osler's studies on platelets were probably his most significant original scientific contribution, they have not generally received much attention. . ." (Marvin J. Stone, "William Osler's Legacy and his Contribution to Haematology", British Journal of Haematology, Vol. 123, 2003, p. 10.). N° de ref. del artículo 17220

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