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Taschenbuch. Condición: Neu. Neuware -Modeling Ships and Space Craft: The Science and Art of Mastering the Oceans and Sky begins with the theories of Aristotle and Archimedes, moving on to examine the work of Froude and Taylor, the early aviators and the Wright Brothers, Goddard and the other rocket men, and the computational fluid dynamic models of our time. It examines the ways each used fluid dynamic principles in the design of their vessels. In the process, this book covers the history of hydrodynamic (aero and fluid) theory and its progression ¿ with some very accessible science examples ¿ including seminal theories. Hydrodynamic principles in action are also explored with examples from nature and the works of man. This is a book for anyone interested in the history of technology ¿ specifically the methods and science behind the use of scale models and hydrodynamic principles in the marine and aeronautical designs of today.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 264 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Fast Compact Algorithms and Software for Spline Smoothing investigates algorithmic alternatives for computing cubic smoothing splines when the amount of smoothing is determined automatically by minimizing the generalized cross-validation score. These algorithms are based on Cholesky factorization, QR factorization, or the fast Fourier transform. All algorithms are implemented in MATLAB and are compared based on speed, memory use, and accuracy. An overall best algorithm is identified, which allows very large data sets to be processed quickly on a personal computer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 56 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Linear algebra is the branch of mathematics that has grown from a care ful study of the problem of solving systems of linear equations. The ideas that developed in this way have become part of the language of much of higher mathematics. They also provide a framework for appli cations of linear algebra to many problems in mathematics, the natural sciences, economics, and computer science. This book is the revised fourth edition of a textbook designed for upper division courses in linear algebra. While it does not presuppose an earlier course, many connections between linear algebra and under graduate analysis are worked into the discussion, making it best suited for students who have completed the calculus sequence. For many students, this may be the first course in which proofs of the main results are presented on an equal footing with methods for solving numerical problems. The concepts needed to understand the proofs are shown to emerge naturally from attempts to solve concrete problems. This connection is illustrated by worked examples in almost every section. Many numerical exercises are included, which use all the ideas, and develop important techniques for problem-solving. There are also theoretical exercises, which provide opportunities for students to discover interesting things for themselves, and to write mathematical explanations in a convincing way. Answers and hints for many of the problems are given in the back. Not all answers are given, however, to encourage students to learn how to check their work.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Geometric constructions have been a popular part of mathematics throughout history. The ancient Greeks made the subject an art, which was enriched by the medieval Arabs but which required the algebra of the Renaissance for a thorough understanding. Through coordinate geometry, various geometric construction tools can be associated with various fields of real numbers. This book is about these associations. As specified by Plato, the game is played with a ruler and compass. The first chapter is informal and starts from scratch, introducing all the geometric constructions from high school that have been forgotten or were never seen. The second chapter formalizes Plato's game and examines problems from antiquity such as the impossibility of trisecting an arbitrary angle. After that, variations on Plato's theme are explored: using only a ruler, using only a compass, using toothpicks, using a ruler and dividers, using a marked rule, using a tomahawk, and ending with a chapter on geometric constructions by paperfolding. The author writes in a charming style and nicely intersperses history and philosophy within the mathematics. He hopes that readers will learn a little geometry and a little algebra while enjoying the effort. This is as much an algebra book as it is a geometry book. Since all the algebra and all the geometry that are needed is developed within the text, very little mathematical background is required to read this book. This text has been class tested for several semesters with a master's level class for secondary teachers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Mathematics students generally meet the Riemann integral early in their undergraduate studies, then at advanced undergraduate or graduate level they receive a course on measure and integration dealing with the Lebesgue theory. However, those whose interests lie more in the direction of applied mathematics will in all probability find themselves needing to use the Lebesgue or Lebesgue-Stieltjes Integral without having the necessary theoretical background. It is to such readers that this book is addressed. The authors aim to introduce the Lebesgue-Stieltjes integral on the real line in a natural way as an extension of the Riemann integral. They have tried to make the treatment as practical as possible. The evaluation of Lebesgue-Stieltjes integrals is discussed in detail, as are the key theorems of integral calculus as well as the standard convergence theorems. The book then concludes with a brief discussion of multivariate integrals and surveys ok L^p spaces and some applications. Exercises, which extend and illustrate the theory, and provide practice in techniques, are included. Michael Carter and Bruce van Brunt are senior lecturers in mathematics at Massey University, Palmerston North, New Zealand. Michael Carter obtained his Ph.D. at Massey University in 1976. He has research interests in control theory and differential equations, and has many years of experience in teaching analysis. Bruce van Brunt obtained his D.Phil. at the University of Oxford in 1989. His research interests include differential geometry, differential equations, and analysis. His publications includeSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Impulsive Control in Continuous and Discrete-Continuous Systems is an up-to-date introduction to the theory of impulsive control in nonlinear systems. This is a new branch of the Optimal Control Theory, which is tightly connected to the Theory of Hybrid Systems. The text introduces the reader to the interesting area of optimal control problems with discontinuous solutions, discussing the application of a new and effective method of discontinuous time-transformation. With a large number of examples, illustrations, and applied problems arising in the area of observation control, this book is excellent as a textbook or reference for a senior or graduate-level course on the subject, as well as a reference for researchers in related fields.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 464 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The Fourier transform and the Laplace transform of a positive measure share, together with its moment sequence, a positive definiteness property which under certain regularity assumptions is characteristic for such expressions. This is formulated in exact terms in the famous theorems of Bochner, Bernstein-Widder and Hamburger. All three theorems can be viewed as special cases of a general theorem about functions qJ on abelian semigroups with involution (S, +, \*) which are positive definite in the sense that the matrix (qJ(sJ + Sk» is positive definite for all finite choices of elements St, . . . , Sn from S. The three basic results mentioned above correspond to (~, +, x\* = -x), ([0, 00[, +, x\* = x) and (No, +, n\* = n). The purpose of this book is to provide a treatment of these positive definite functions on abelian semigroups with involution. In doing so we also discuss related topics such as negative definite functions, completely mono tone functions and Hoeffding-type inequalities. We view these subjects as important ingredients of harmonic analysis on semigroups. It has been our aim, simultaneously, to write a book which can serve as a textbook for an advanced graduate course, because we feel that the notion of positive definiteness is an important and basic notion which occurs in mathematics as often as the notion of a Hilbert space.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available.This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 472 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Modified atmosphere packaging (MAP) has proved to be one of the most significant and innovative growth areas in retail food packaging of the past two decades. Bulk modified atmosphere packs have been an accepted form of packaging for meat and poultry in the USA since the early 1970s, but MAP is only now of being widely adopted. Today there is a substantial wholesale on the verge market for bulk packaged fresh vegetables and fruit, and the most significant retail MAP products are fresh pasta, pre-cooked poultry and sausage, and biscuits (a unique American product). The United Kingdom is the biggest single market for the modified atmosphere packaging of fresh chilled food products, accounting for about half of the total European market. A further quarter is represented by France. The success of MAP in both the British and French markets can be attributed to the large, highly sophisticated food retailing multiples and dense populations existing in both countries.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The aim of this textbook is to provide undergraduate students with an introduction to the basic theoretical models of computability, and to develop some of the model's rich and varied structure. Students who have already some experience with elementary discrete mathematics will find this a well-paced first course, and a number of supplementary chapters introduce more advanced concepts. The first part of the book is devoted to finite automata and their properties. Pushdown automata provide a broader class of models and enable the analysis of context-free languages. In the remaining chapters, Turing machines are introduced and the book culminates in discussions of effective computability, decidability, and Gödel's incompleteness theorems. Plenty of exercises are provided, ranging from the easy to the challenging. As a result, this text will make an ideal first course for students of computer science.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 420 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The Color Atlas of 'Xenopus laevis' Histology provides the first central source on the microscopic anatomy of cells, tissues, and major organs of the adult South African clawed frog, Xenopus laevis. For many years, X. laevis has been a highly popular experimental animal model in many areas of research. The recent development of transgenic Xenopus technology offers the promise that this animal model will be utilized more than ever before. The purpose of this book is to provide the active researcher with a central source of high quality light microscopic color images of the tissues of X. laevis, to aid in the identification of the cells and tissues of interest.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Mechanical Engineering, an engineering discipline borne of the needs of the in dustrial revolution, is once again asked to do its substantial share in the call for industrial renewal. The general call is urgent as we face profound issues of pro ductivity and competitiveness that require engineering solutions, among others. The Mechanical Engineering Series features graduate texts and research mono graphs intended to address the need for information in contemporary areas ofme chanical engineering. The series is conceived as a comprehensive one that covers a broad range of concentrations important to mechanical engineering graduate education and re search. We are fortunate to have a distinguished roster ofconsulting editors on the advisory board, each an expert in one ofthe areas ofconcentration. The names of the consulting editors are listed on the next page of this volume. The areas of concentration are applied mechanics, biomechanics, computational mechanics, dynamic systems and control, energetics, mechanics ofmaterials, processing, ther mal science, and tribology. Frederick A. Leckie,the series editor for applied mechanics, and I are pleased to presentthis volume in the Series: Nonlinear Computational Structural Mechan ics: New Approaches and Non-Incremental Methods of Calculation, by Pierre Ladeveze. The selection of this volume underscores again the interest of the Me chanical Engineering series to provide our readers with topical monographs as well as graduate texts in a wide variety of fields.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such 'angiogenic diseases' have been described where angiogeneSiS is involved. Also in tumor growth and metastasis angiogenesis is an essential process and precedes neoplastic transformation. Hence, angiogenesis could become an important diagnostic tool and a target for developing therapeutic agents. This book contains the proceedings of the NATO Advanced Study Institute on 'Angiogenesis in Health and Disease' held in Porto Hydra, Greece, from June 16-27, 1991. This meeting was a comprehensive review of endothelial cell biology and endothelial cell phenotypic and functional heterogeneity in relation to angiogenesis under physiological and pathological conditions. Numerous in vitro and in vivo models were presented, which are used to study angiogenesis at the molecular and cellular levels and to evaluate chemical compounds or naturally occuring substances for their effect on angiogenesis. The presentations and discussions at this meeting provided an opportunity for the basic science and the clinical disciplines to meet, exchange information and provide future research directions for many investigators engaged in the study of angiogenesis.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Proceedings of the XIIIth International Symposium, held in Santiago, Chile, March 25-29, 1996Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 500 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Advanced ASIC Chip Synthesis: Using Synopsys® Design Compiler® and PrimeTime® describes the advanced concepts and techniques used for ASIC chip synthesis, formal verification and static timing analysis, using the Synopsys suite of tools. In addition, the entire ASIC design flow methodology targeted for VDSM (Very-Deep-Sub-Micron) technologies is covered in detail.The emphasis of this book is on real-time application of Synopsys tools used to combat various problems seen at VDSM geometries. Readers will be exposed to an effective design methodology for handling complex, sub-micron ASIC designs. Significance is placed on HDL coding styles, synthesis and optimization, dynamic simulation, formal verification, DFT scan insertion, links to layout, and static timing analysis. At each step, problems related to each phase of the design flow are identified, with solutions and work-arounds described in detail. In addition, crucial issues related to layout, which includes clock tree synthesis and back-end integration (links to layout) are also discussed at length. Furthermore, the book contains in-depth discussions on the basics of Synopsys technology libraries and HDL coding styles, targeted towards optimal synthesis solutions.Advanced ASIC Chip Synthesis: Using Synopsys® Design Compiler® and PrimeTime® is intended for anyone who is involved in the ASIC design methodology, starting from RTL synthesis to final tape-out. Target audiences for this book are practicing ASIC design engineers and graduate students undertaking advanced courses in ASIC chip design and DFT techniques.From the Foreword:`This book, written by Himanshu Bhatnagar, provides a comprehensive overview of the ASIC design flow targeted for VDSM technologies using the Synopsis suite of tools. It emphasizes the practical issues faced by the semiconductor design engineer in terms of synthesis and the integration offront-end and back-end tools. Traditional design methodologies are challenged and unique solutions are offered to help define the next generation of ASIC design flows. The author provides numerous practical examples derived from real-world situations that will prove valuable to practicing ASIC design engineers as well as to students of advanced VLSI courses in ASIC design'.Dr Dwight W. Decker, Chairman and CEO, Conexant Systems, Inc., (Formerly, Rockwell Semiconductor Systems), Newport Beach, CA, USA.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth.There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of niches, including the soil, the plant rhizosphere and phylosphere, and animal tissues; more recently they have attracted attention because of their capacity to form biofilms, a characteristic with potentially important medical and environmental implications.The three volumes cover the following topics: Taxonomy Genomics Life styles Cell Architecture Virulence Regulation Macromolecules Alternative Respiratory Substrates Catabolism and Biotransformations. Pseudomonas will be of use to all researchers working on these bacteria, particularly those studying microbiology, plant crops, pathogenesis, and chemical engineering. Advanced students in biology, medicine and agronomy will also find these three volumes a valuable reference during their studies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 768 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Management of wild waterfowl has become increasingly intensive. Many birds now hatch in managed nesting cover or in artificial nesting structures, use man-made wetlands, and winter on crowded refuges while consuming a grain diet The water they use is often limited in supply and may contain residues from its many prior users. Unfortunately, intensified management often results in new problems, among which disease is important There are many similarities between the current form of management used for some waterfowl and that used in domestic animals. In both, the objective is to maintain a healthy, productive population. Dealing with health problems in waterfowl will benefit from combining the skills of veterinary medicine and wildlife ecology. Revisiting this book after 15 years allowed me to consider changes at the interface between the two disciplines. Veterinary medicine traditionally has been concerned with the individual and with treating sick animals, while the ecologist is concerned with populations and the manager has limited interest in treating sick birds. During this period there has been a marked increase in awareness among veterinarians that they have a responsibility in wildlife and conservation biology. Curricula of many veterinary colleges now include material on non-domestic animals and attempt to put disease in an ecological context. Also during this time, waterfowl managers have become more aware of disease as a factor in population biology and there are early attempts to put numbers to 'disease' in models of continental waterfowl populations.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -While this volume is based on an earlier work, An Anatomy of Speech Notions (1976), the overall orientation of the present volume is distinctive enough to make it a new work. The former volume was essentially a half-way house to discourse. While including a chapter on discourse struc ture, it was not as a whole explicitly oriented towards con siderations of context. The present volume, however, strives to achieve a more consistently contextual approach to lan guage. A great deal of research and theorizing concerning discourse grammar or textlinguistics has characterized the past decade of linguistic studies. This recent work has, of course, influenced the present volume. In addition, my personal research in several areas has led to increased insistence on the indispensability of discourse studies. Crucial here was my direction of field workshops involving personnel of the Summer Institute of Linguistics, first in relation to languages of Colombia, Panama, and Ecuador (1974- 1975), and later in relation to languages of Mexico (1978). Of further relevance have been my own studies of narrative structure in Biblical Hebrew. Last but not least, is the stimulus and feedback which I have received from my graduate students (whose research is embodied in several theses and dissertations), especially Keith Beavon, Shin Ja Joo Huang, Larry Jones, Mildred Larson, Linda Lloyd, and Mike Walrod.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 448 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -¿While the analysis is not the first to investigate empirically the effects of different individual or household factors on school access and completion of Ghanaians, it extends previous work by simultaneously incorporating individual, household, community, regional and national characteristics and also illustrates the latest evidence by applying international data sources and unusually detailed household survey data for a sub-Saharan country. Its focus is threefold: (i) gaining a richer understanding of which external influences hinder educational access and attainment in Ghana, (ii) how to better tackle these challenges and (iii) analyzing how educational development affects the country¿s overall development. An interview with the Minister of Education helps guide the policy orientation of the analysis by identifying several critical challenges and areas of needed policy attention. Findings from the data analysis indicate that the geographic divide between the North and South, increased economic growth, demographic pressure and a number of individual, household and community factors especially children¿s nutritional and labour status are the most important challenges in increasing levels of education among Ghanaians in years to come. Finally, the analysis pilots a new and comprehensive results- and capacity-focused policy matrix to help the Government of Ghana realign policy priorities and reform existing programs. To this end, respective policy levers on the demand- and supply-side are discussed, with particular reference to external and demand-side interventions which have not received the necessary attention at the policy-level to improve educational opportunities and outcomes at all levels.¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 156 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The use oflubricants began in ancient times and has developed into a major international business through the need to lubricate machines of increasing complexity. The impetus for lubricant development has arisen from need, so lubricatingpractice has precededan understandingofthescientificprinciples. This is not surprising as the scientific basis of the technology is, by nature, highly complex and interdisciplinary. However, we believe that the under standing of lubricant phenomena will continue to be developed at a mol ecular level to meet future challenges. These challenges will include the control of emissions from internal combustion engines, the reduction of friction and wear in machinery, and continuing improvements to lubricant performanceand life-time. More recently, there has been an increased understanding ofthe chemical aspects of lubrication, which has complemented the knowledge and under standing gained through studies dealing with physics and engineering. This book aims to bring together this chemical information and present it in a practical way. It is written by chemists who are authorities in the various specialisations within the lubricating industry, and is intended to be of interest to chemists who may already be working in the lubricating industry or in academia, and who are seeking a chemist's view of lubrication. It will also be of benefit to engineers and technologists familiar with the industry who requirea more fundamental understanding oflubricants.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -On September 17 and 18, 1998, a conference took place at Mont Tremblant on the theme 'Doing Business in a Knowledge-Based Economy.' This conference brought together some hundred participants from government, business and academia, with backgrounds in business administration, engineering, public administration and economics, to provide a multidisciplinary analysis of what has come to be known as the 'Knowledge-Based Economy' (KBE). The aim was to come up with suggestions and recommendations about how to do business in a knowledge based economy, both at the firm level and at the government level. All presenters were explicitly asked to conclude with policy recommendations. The conference was sponsored by Industry Canada and organized by the Centre of Interuniversity Research on the Analysis of Organizations (CIRANO). The conference papers offered U.S., Canadian and European perspectives on the management of a knowledge-based economy. This volume is divided into three parts. The papers in part I set the stage by describing the salient features of the KBE. What is so special about it What are its economic underpinnings What are its technological characteristics Knowledge plays a crucial role in a KBE, hence its name. Whereas, in the past, growth was determined primarily by the availability of land, natural resources, labour and capital successively, at the end of the twentieth century, knowledge has become a (if not the) major factor of economic growth.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 512 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -In the future, as our society becomes older and older, an increasing number of people will be confronted with Alzheimer's disease. Some will suffer from the illness themselves, others will see parents, relatives, their spouse or a close friend afflicted by it. Even now, the psychological and financial burden caused by Alzheimer's disease is substantial, most of it borne by the patient and her family. Improving the situation for the patients and their caregivers presents a challenge for societies and decision makers. Our work contributes to improving the in decision making situation con cerning Alzheimer's disease. At a fundamental level, it addresses methodo logical aspects of the contingent valuation method and gives a holistic view of applying the contingent valuation method for use in policy. We show all stages of a contingent valuation study beginning with the design, the choice of elicitation techniques and estimation methods for willingness-to-pay, the use of the results in a cost-benefit analysis, and finally, the policy implica tions resulting from our findings. We do this by evaluating three possible programs dealing with Alzheimer's disease. The intended audience of this book are health economists interested in methodological problems of contin gent valuation studies, people involved in health care decision making, plan ning, and priority setting, as well as people interested in Alzheimer's disease. We would like to thank the many people and institutions who have pro vided their help with this project.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 132 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Throughout the development of mathematical programming researchers have paid great attention to problems that are described by a single objective that can only be achieved subject to satisfying a set of restrictions or constraints. Recently, it has been recognized that the use of a single objective limits the applicability of In reality, many multiobjective mathematical programming models. situations exist and frequently these mUltiple objectives are in direct conflict. Research on multiobjective problems can be broken down into two broad categories: multiobjective optimization and multicriterion decision theory. Multiobjective optimization models are based on techniques such as linear programming. In general, the multiobjective optimization problem can be defined as finding a feasible alternative that yields the most preferred set of values for the objective functions. This problem differs from a single objective because subjective methods are required to determine which alternative is most preferred. A body of literature parallel to that m multiobjective optimization has been developing in the area of multicriterion decision theory. These models are based on classical decision analysis, particularly utility theory. One focus of this research has been the development and testing of procedures for estimating multiattribute utility functions that are consistent with rational decision maker behavior. A utility function provides a model of a decision maker's choice among alternatives. This literature is directly xii MULTIOBJECTIVE OPTIMIZATION applicable to multiobjective optimization and provides much needed insight into the subjective character of that problem.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -There are over a million different species of insects, and individually they 8 outnumber humans by more than 10 to 1. Moreover, some insects live in close association with both plants and higher animals and naturally exchange viruses with them. It has even been speculated that viruses in general may have radiated through the plant and animal kingdoms from common insect origins. Be that as it may, since insects play pivotal roles in the biosphere, both to the benefit and detriment of mankind, they and the viruses that infect them are important subjects for study. Insects are infected by a diverse medley of viruses, and this volume focuses on those insect virus families that are found primarily or exclusively in insects. All major families of insect-selective viruses are covered except for the baculo viruses, which were described in a separate volume of The Viruses series. Included in this volume are the established families of insect viruses, the newly recognized ascovirus family, and the nudiviruses, which probably represent a separate family but currently remain unclassified. The coverage of arboviruses is limited to a single chapter that focuses on their potential utility as vectors and in insect control. Omitted for practical reasons are several individual insect viruses that have been described sporadically in the literature and probably represent novel virus families.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 444 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Anonymization of Electronic Medical Records to Support Clinical Analysis closely examines the privacy threats that may arise from medical data sharing, and surveys the state-of-the-art methods developed to safeguard data against these threats.To motivate the need for computational methods, the book first explores the main challenges facing the privacy-protection of medical data using the existing policies, practices and regulations. Then, it takes an in-depth look at the popular computational privacy-preserving methods that have been developed for demographic, clinical and genomic data sharing, and closely analyzes the privacy principles behind these methods, as well as the optimization and algorithmic strategies that they employ. Finally, through a series of in-depth case studies that highlight data from the US Census as well as the Vanderbilt University Medical Center, the book outlines a new, innovative class of privacy-preserving methods designed to ensure the integrityof transferred medical data for subsequent analysis, such as discovering or validating associations between clinical and genomic information.Anonymization of Electronic Medical Records to Support Clinical Analysis is intended for professionals as a reference guide for safeguarding the privacy and data integrity of sensitive medical records. Academics and other research scientists will also find the book invaluable.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 88 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The dairy industry is, in many countries, a major contributor to the manufacturing capacity of the food sector, and as more components of milk are utilised in processed foods, so this importance is likely to grow. Already dairy operations range from the straightforward handling of liquid milk through to the production of highly sophisticated consumer items, and it is of note that all this activity is based on a raw material that is readily perishable at ambient temperatures. This competitive, commercial position, together with the fact that the general public has a high regard for dairy products, is an indication of the extent to which milk producers and processors have combined to ensure that retail prO(;lucts are both nutritious and hygienically acceptable. Achievement of these aims, and at reasonable cost, has depended in large measure on the advances that have been made in the handling of large volumes of milk. Thus, factories designed to handle millions of litres of milk per weekare now commonplace, and it is the plant and equipment involved that provides the factual background for this two-volume book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 500 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -The gratifying response to Counterexamples in analysis (CEA) was followed, when the book went out of print, by expressions of dismay from those who were unable to acquire it. The connection of the present volume with CEA is clear, although the sights here are set higher. In the quarter-century since the appearance of CEA, mathematical education has taken some large steps reflected in both the undergraduate and graduate curricula. What was once taken as very new, remote, or arcane is now a well-established part of mathematical study and discourse. Consequently the approach here is designed to match the observed progress. The contents are intended to provide graduate and ad vanced undergraduate students as well as the general mathematical public with a modern treatment of some theorems and examples that constitute a rounding out and elaboration of the standard parts of algebra, analysis, geometry, logic, probability, set theory, and topology. The items included are presented in the spirit of a conversation among mathematicians who know the language but are interested in some of the ramifications of the subjects with which they routinely deal. Although such an approach might be construed as demanding, there is an extensive GLOSSARY jlNDEX where all but the most familiar notions are clearly defined and explained. The object ofthe body of the text is more to enhance what the reader already knows than to review definitions and notations that have become part of every mathematician's working context.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 344 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ¿What is a Stem Cell¿ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.¿ 96 pp. Englisch.

Taschenbuch. Condición: Neu. Neuware -These Proceedings contain the contributions of the partIcIpants of the Third International Symposium on Dendritic Cells that was held in Annecy, France, from June 19 to June 24, 1994. This symposium represented a follow-up of the first and second international symposia that were held in Japan in 1990 and in the Netherlands in 1992. Dendritic cells are antigen-presenting cells, and are found in all tissues and organs of the body. They can be classified into: (1) interstitial dendritic cells of the heart, kidney, gut, and lung;(2) Langerhans cells in the skin and mucous membranes; (3) interdigitating dendritic cells in the thymic medulla and secondary lymphoid tissue; and (4) blood dendritic cells and lymph dendritic cells (veiled cells). Although dendritic cells in each of these compartments are all CD45+ leukocytes that arise from the bone marrow, they may exhibit differences that relate to maturation state and microenvironment. Dendritic cells are specialized antigen-presenting cells for T lymphocytes: they process and present antigens efficiently in situ, and stimulate responses from naive and memory T cells in the paracortical area of secondary lymphoid organs. Recent evidence also demonstrates their role in induction of tolerance. By contrast, the primary and secondary B-cell follicles contain follicular dendritic cells that trap and retain intact antigen as immune complexes for long periods of time. The origin of follicular dendritic cells is not clear, but most investigators believe that these cells are not leukocytes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 596 pp. Englisch.