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Publicado por LAP LAMBERT Academic Publishing Jun 2017, 2017
ISBN 10: 3330328800ISBN 13: 9783330328808
Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Alemania
Libro Impresión bajo demanda
Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The objective of this study was to investigate the in vitro interactions of lisinopril with metformin using the principle of the dissolution test. The study was conducted using the USP apparatus II paddle method with the temperature set at 37 C body temperature. The media used were buffer pH 1.2, 4.5, and 6.8 to simulate gastrointestinal tract pH. Lisinopril tablets (10 mg strength) were run in the presence of 500 mg metformin tablets and the degree of interaction was established after analyzing the dissolution samples with High-Performance Liquid Chromatography coupled with a ultra-violet detector. The results indicated a statistically significant difference in the effect of lisinopril on the dissolution profile of metformin at pH 1.2, 4.5, and 6.8, with a decrease in the percentage of metformin, released (p = 0.0052; p = 0.0037; and p = 0.0155, respectively). The effect of metformin on the dissolution profile of lisinopril was statistically significant at pH 1.2 and 6.8 with an increase in the percentage of lisinopril released (p = 0.0062; p =0.0036, respectively). However, there was no statistically significant difference at pH 4.5 (p = 0.7174). 100 pp. Englisch.
Publicado por LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330328800ISBN 13: 9783330328808
Librería: AHA-BUCH GmbH, Einbeck, Alemania
Libro Impresión bajo demanda
Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of this study was to investigate the in vitro interactions of lisinopril with metformin using the principle of the dissolution test. The study was conducted using the USP apparatus II paddle method with the temperature set at 37 C body temperature. The media used were buffer pH 1.2, 4.5, and 6.8 to simulate gastrointestinal tract pH. Lisinopril tablets (10 mg strength) were run in the presence of 500 mg metformin tablets and the degree of interaction was established after analyzing the dissolution samples with High-Performance Liquid Chromatography coupled with a ultra-violet detector. The results indicated a statistically significant difference in the effect of lisinopril on the dissolution profile of metformin at pH 1.2, 4.5, and 6.8, with a decrease in the percentage of metformin, released (p = 0.0052; p = 0.0037; and p = 0.0155, respectively). The effect of metformin on the dissolution profile of lisinopril was statistically significant at pH 1.2 and 6.8 with an increase in the percentage of lisinopril released (p = 0.0062; p =0.0036, respectively). However, there was no statistically significant difference at pH 4.5 (p = 0.7174).
Publicado por LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330328800ISBN 13: 9783330328808
Librería: moluna, Greven, Alemania
Libro Impresión bajo demanda
Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Amorha Kosisochi ChinwenduKosisochi Chinwendu Amorha is a pharmacist and lecturer at the Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka (UNN).The objective of this study was to investigate .
Publicado por LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330328800ISBN 13: 9783330328808
Librería: Revaluation Books, Exeter, Reino Unido
Libro
Paperback. Condición: Brand New. 100 pages. 8.66x5.91x0.23 inches. In Stock.
Publicado por LAP LAMBERT Academic Publishing, 2017
ISBN 10: 3330328800ISBN 13: 9783330328808
Librería: Mispah books, Redhill, SURRE, Reino Unido
Libro
paperback. Condición: New. NEW. book.