Tipo de artículo
Condición
Encuadernación
Más atributos
Ubicación del vendedor
Valoración de los vendedores
Publicado por LAP LAMBERT Academic Publishing Sep 2010, 2010
ISBN 10: 3838325001ISBN 13: 9783838325002
Librería: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Alemania
Libro Impresión bajo demanda
Taschenbuch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A in many human cancers suggest PP2A-A is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A reducing its ability to bind the PP2A complex. Transfecting the PP2A-A gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A are found to have lower levels of -catenin, suggesting the PP2A-A gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer. 80 pp. Englisch.
Publicado por LAP LAMBERT Academic Publishing, 2009
ISBN 10: 3838325001ISBN 13: 9783838325002
Librería: AHA-BUCH GmbH, Einbeck, Alemania
Libro Impresión bajo demanda
Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The most common cancers of adults include lung, colon and breast carcinoma. The PP2A-A gene (PPP2R1B) encodes a component of protein phosphatase 2A. The important role of protein phosphatase 2A in down regulating cell growth and the mutations of PP2A-A in many human cancers suggest PP2A-A is a tumor suppressor gene. Screening of cancer patient DNAs revealed alterations of PP2A-A in various cancers and a germline alteration associated with breast carcinoma. Biochemical studies showed mutations in PP2A-A reducing its ability to bind the PP2A complex. Transfecting the PP2A-A gene into cancer cell lines conferred a relative growth disadvantage to transfected cells. Cell lines expressing exogenous PP2A-A are found to have lower levels of -catenin, suggesting the PP2A-A gene is involved in regulating the Wnt signaling pathway. These studies elucidate the tumor suppressor qualities of the PP2A-A gene, its role in heritable cancer susceptibility, the potential it has as a target for gene directed therapy of cancer, and should be useful to professionals studying the mechanisms and treatment of cancer.
Publicado por LAP LAMBERT Academic Publishing, 2010
ISBN 10: 3838325001ISBN 13: 9783838325002
Librería: moluna, Greven, Alemania
Libro Impresión bajo demanda
Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: ESPLIN EDWARDThe son of Helen and D. Glen Esplin, married to his lovely wife Michal. A.A. at Dixie College, B.A. Biology and German at University of Utah, served a mission for the Church of Jesus Christ of Latter-day Saints in Zueri.
Publicado por Lap Lambert Academic Publishing, 2009
ISBN 10: 3838325001ISBN 13: 9783838325002
Librería: Revaluation Books, Exeter, Reino Unido
Libro
Paperback. Condición: Brand New. 80 pages. 8.66x5.91x0.19 inches. In Stock.