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Phosphodiesterases as Drug Targets (Hardback)

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ISBN 10: 3642179681 / ISBN 13: 9783642179686
Editorial: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany, 2011
Nuevos Condición: New Encuadernación de tapa dura
Librería: The Book Depository EURO (London, Reino Unido)

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Language: English. Brand new Book. Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. N° de ref. de la librería SPR9783642179686

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Título: Phosphodiesterases as Drug Targets (Hardback...

Editorial: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany

Año de publicación: 2011

Encuadernación: Hardback

Condición del libro: New

Edición: 2011.

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Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

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