Imagen del editor
Imagen no disponible

Methylglyoxal-Lowering Agents as a Treatment for Alzheimer's Disease? (Paperback)

Martina Krautwald

ISBN 10: 3844316183 / ISBN 13: 9783844316186
Editorial: LAP Lambert Academic Publishing, Germany, 2011
Nuevos Condición: New Encuadernación de tapa blanda
Librería: The Book Depository EURO (London, Reino Unido)

Librería en AbeBooks desde: 29 de abril de 2014 Valoración librería Valoración 3 estrellas

Cantidad disponible: 1

Comprar nuevo
Precio: EUR 73,49 Convertir moneda
Gastos de envío: EUR 3,60 De Reino Unido a Estados Unidos de America Destinos, gastos y plazos de envío
Añadir al carrito

Descripción

Language: English. Brand new Book. Advanced glycation end products (AGEs) play a major role in age-related diseases like Alzheimer's disease. 1,2-dicarbonyl compounds, such as glyoxal (GO) and methylglyoxal (MGO), are involved in the formation of these AGEs. Thus, it was hypothesised that the progression of Alzheimer's disease can be slowed down by lowering the concentration of 1,2-dicarbonyl compounds, which will consequently lead to a decrease in AGE formation. Therefore, the aim of this work was to establish an HPLC-method for the detection of glyoxal and methylglyoxal from cultured cells in order to determine the potential of different agents to lower the concentration of these 1,2-dicarbonyl compounds. Furthermore, it was assessed whether ALT-711 (Alagebrium), an AGE lowering agent, is an inhibitor of the enzyme thiamine diphosphokinase, due to its structural homology to the enzyme's natural substrate thiamine. This enzyme is responsible for the formation of thiamine diphosphate, the co-factor of the enzyme transketolase which is involved in the degradation of methylglyoxal. Thus, inhibition of thiamine diphosphokinase activity would counteract with ALT-711's main AGE lowering effect. N° de ref. de la librería KNV9783844316186

Hacer una pregunta a la librería

Detalles bibliográficos

Título: Methylglyoxal-Lowering Agents as a Treatment...

Editorial: LAP Lambert Academic Publishing, Germany

Año de publicación: 2011

Encuadernación: Paperback

Condición del libro: New

Acerca de

Reseña del editor:

Advanced glycation end products (AGEs) play a major role in age-related diseases like Alzheimer's disease. 1,2-dicarbonyl compounds, such as glyoxal (GO) and methylglyoxal (MGO), are involved in the formation of these AGEs. Thus, it was hypothesised that the progression of Alzheimer's disease can be slowed down by lowering the concentration of 1,2-dicarbonyl compounds, which will consequently lead to a decrease in AGE formation. Therefore, the aim of this work was to establish an HPLC-method for the detection of glyoxal and methylglyoxal from cultured cells in order to determine the potential of different agents to lower the concentration of these 1,2-dicarbonyl compounds. Furthermore, it was assessed whether ALT-711 (Alagebrium), an AGE lowering agent, is an inhibitor of the enzyme thiamine diphosphokinase, due to its structural homology to the enzyme's natural substrate thiamine. This enzyme is responsible for the formation of thiamine diphosphate, the co-factor of the enzyme transketolase which is involved in the degradation of methylglyoxal. Thus, inhibition of thiamine diphosphokinase activity would counteract with ALT-711's main AGE lowering effect.

"Sobre este título" puede pertenecer a otra edición de este libro.

Descripción de la librería

The Book Depository - bookdepository.com - is the UK's largest dedicated online bookseller offering the largest range of titles in the world, available for dispatch within 48 hours. Founded in 2004 to make 'All Books To All' we focus on selling 'less of more' rather than 'more of less', differentiating ourself from other retailers who increasingly focus on bestsellers. All books available to All Currently, The Book Depository is able to ship over 4 million unique titles, within 48 hours, from our fulfillment centre in Gloucester, United Kingdom. This figure is increasing everyday. Apart from publishers, distributors and wholesalers, we even list and supply books from other retailers!

Ver la página web de la librería

Condiciones de venta:

All books are shipped in New condition promptly, we are
happy to accept returns up to 30 days from purchase. Orders
usually ship within 1-2 business days. Domestic Shipments
are sent by Royal Mail, and International by Priority
Airmail. We are happy to accept returns up to 30 days from
purchase.

¿ Name of business : The Book Depository Ltd
¿ Form of legal entity : A Limited Company
¿ Business address: The Book Depository, Thames Central, Hatfield Road,
Slough, Berkshire, SL1 1QE
¿ Email address:...

Más información
Condiciones de envío:

Orders usually ship within 1-2 business days. Domestic Shipments are sent by Royal
Mail, and International by Priority Airmail. Orders usually ship within 1-2
business days. Domestic Shipments are sent by Royal Mail, and International by
Priority Airmail. We are happy to accept returns up to 30 days from purchase.
Please contact the seller directly if you wish to return an order.

Todos los libros de esta librería

Métodos de pago
aceptados por la librería

Visa Mastercard American Express Carte Bleue