A Live Escherichia coli Vaccine for Poultry: Prevention of Colibacillosis

ISBN 10: 3845412755 / ISBN 13: 9783845412757
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A Live Escherichia coli Vaccine for Poultry: Prevention of Colibacillosis. N° de ref. de la librería

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Sinopsis: In spite of widespread use of antibacterial agents to control colibacillosis in poultry, the development of an effective vaccine has been an important goal for researchers. Compared to bacterins and subunit vaccines, live vaccines are attractive because they are much cheaper than purified proteins, and can be used for mass immunization via aerosol, feed, or drinking water. Our goals in this research were to construct non-revertible mutant derivatives of avian pathogenic strains of E. coli and to evaluate their potential ability to protect chickens against experimental disease. ?cya ?crp mutants of two avian septicemic E. coli strains were constructed and shown to be attenuated in virulence and non-reverting. The immunogenicity and efficacy of the double mutant strains were assessed in an aerosol-based challenge model. The present vaccine has the potential to be inexpensive and effective against E. coli infections in poultry. When the laboratory studies indicate that there is greater protection against the experimental challenge, a field trial is needed as challenge under the natural environment may be quite different from the single massive exposure that is used experimentally.

Biografía del autor: Dr. S. M. Peighambari received his DVM in 1986 from University of Tehran (Iran); MSc. in 1994, and Ph.D in 1998 (both in Veterinary Microbiology) from University of Guelph (Canada). Currently, Dr. Peighambari is an associate professor at the University of Tehran working on diseases of birds and has authored many publications in scientific journals

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Título: A Live Escherichia coli Vaccine for Poultry:...
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Peighambari, Seyed Mostafa
Editorial: LAP Lambert Academic Publishing (2011)
ISBN 10: 3845412755 ISBN 13: 9783845412757
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Descripción LAP Lambert Academic Publishing, Germany, 2011. Paperback. Estado de conservación: New. 218 x 147 mm. Language: English . Brand New Book ***** Print on Demand *****.In spite of widespread use of antibacterial agents to control colibacillosis in poultry, the development of an effective vaccine has been an important goal for researchers. Compared to bacterins and subunit vaccines, live vaccines are attractive because they are much cheaper than purified proteins, and can be used for mass immunization via aerosol, feed, or drinking water. Our goals in this research were to construct non-revertible mutant derivatives of avian pathogenic strains of E. coli and to evaluate their potential ability to protect chickens against experimental disease. cya crp mutants of two avian septicemic E. coli strains were constructed and shown to be attenuated in virulence and non-reverting. The immunogenicity and efficacy of the double mutant strains were assessed in an aerosol-based challenge model. The present vaccine has the potential to be inexpensive and effective against E. coli infections in poultry. When the laboratory studies indicate that there is greater protection against the experimental challenge, a field trial is needed as challenge under the natural environment may be quite different from the single massive exposure that is used experimentally. Nº de ref. de la librería AAV9783845412757

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Descripción LAP LAMBERT Academic Publishing, 2011. Paperback. Estado de conservación: New. book. Nº de ref. de la librería 3845412755

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Seyed Mostafa Peighambari
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Descripción LAP LAMBERT Academic Publishing. Paperback. Estado de conservación: New. Paperback. 120 pages. Dimensions: 8.6in. x 5.8in. x 0.5in.In spite of widespread use of antibacterial agents to control colibacillosis in poultry, the development of an effective vaccine has been an important goal for researchers. Compared to bacterins and subunit vaccines, live vaccines are attractive because they are much cheaper than purified proteins, and can be used for mass immunization via aerosol, feed, or drinking water. Our goals in this research were to construct non-revertible mutant derivatives of avian pathogenic strains of E. coli and to evaluate their potential ability to protect chickens against experimental disease. cya crp mutants of two avian septicemic E. coli strains were constructed and shown to be attenuated in virulence and non-reverting. The immunogenicity and efficacy of the double mutant strains were assessed in an aerosol-based challenge model. The present vaccine has the potential to be inexpensive and effective against E. coli infections in poultry. When the laboratory studies indicate that there is greater protection against the experimental challenge, a field trial is needed as challenge under the natural environment may be quite different from the single massive exposure that is used experimentally. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Nº de ref. de la librería 9783845412757

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