Epilepsy: Animal and Human Correlations

McCandless, David W.

Editorial: Springer, 2011
ISBN 10: 1461401089 / ISBN 13: 9781461401087
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Sinopsis: The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7-9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

From the Back Cover:

Correlation is a vital element in epilepsy research, especially given the condition’s notorious resistance to treatment. With a current ‘rate of translation’ estimated at between seven and nine years, and a translation ‘success rate’ of below 50 per cent, there is room for improvement in the correlative research exploring this intractable condition.

Epilepsy: Animal and Human Correlations offers judiciously selected material with clear correlative relevance. Arranged according to animal studies and related studies in the human population, each chapter covers clinical description, neurophysiology, neurochemistry, neuropathology, and treatment attempts. The human chapters have an additional section detailing studies based on counterpart animal studies, as well as covering promising further research suggested by animal results. The book includes a clear statement of the rationale for future human clinical investigations based on animal results.

The chapters cover animal and human studies related to both simple and complex partial seizures. It covers typical as well as atypical seizures, and includes material on some seizure disorders which resist neat classification. Studies conducted in the primate population receive careful attention

 

 

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encepha

lopathies. He was the Fo

unding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

 

 

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

About the Author:
The work of Dr. David W. McCandless spanne

d over 35 years of laboratory research into basic mechan

isms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

 

 

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

About the Author:
The work of Dr. David W. McCandless spanned o

ver 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

Epilepsy: Animal and Human Correlations offers judiciously selected material with clear correlative relevance. Arranged according to animal studies and related studies in the human population, each chapter covers clinical description, neurophysiology, neurochemistry, neuropathology, and treatment attempts. The human chapters have an additional section detailing studies based on counterpart animal studies, as well as covering promising further research suggested by animal results. The book includes a clear statement of the rationale for future human clinical investigations based on animal results.

The chapters cover animal and human studies related to both simple and complex partial s

eizures. It covers typical as well as atypical seizures, and includes material on some seizure diso

rders which resist neat classification. Studies conducted in the primate population receive careful attention

 

 

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

 

 

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medica

l School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently

, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

The chapters cover animal and human studies related to both simple and complex partial seizures. It covers typical as well as atypical seizures, and includes material on some seizure disorders which resist neat classification. Studies conducted in the primate population receive careful attention

 

 

About the Author:

The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of t

he journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

 

 

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Frankl

in University, North Chicago, IL, USA.

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various me

tabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

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Detalles bibliográficos

Título: Epilepsy: Animal and Human Correlations
Editorial: Springer
Año de publicación: 2011
Encuadernación: Hardcover
Condición del libro: Used: Good

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Descripción Springer-Verlag New York Inc., United States, 2011. Hardback. Estado de conservación: New. 2012. Language: English . Brand New Book ***** Print on Demand *****. The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7-9 years, and the success rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement. Nº de ref. de la librería APC9781461401087

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Descripción Springer-Verlag New York Inc., United States, 2011. Hardback. Estado de conservación: New. 2012. Language: English . Brand New Book ***** Print on Demand *****.The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7-9 years, and the success rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement. Nº de ref. de la librería APC9781461401087

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