Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery (Hardback)

Ewelina Guca

Editorial: John Wiley and Sons Ltd, 2016
ISBN 10: 3527339043 / ISBN 13: 9783527339044
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Language: English . Brand New Book. Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art omics technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented. N° de ref. de la librería

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Sinopsis: WRITTEN AND EDITED BY EXPERTS IN THE FIELD, THIS BOOK BRINGS TOGETHER THE CURRENT STATE OF THE ART IN PHENOTYPIC AND RATIONAL, TARGET–BASED APPROACHES TO DRUG DISCOVERY AGAINST PATHOGENIC PROTOZOA. THE CHAPTERS FOCUS PARTICULARLY ON VIRTUAL COMPOUNDS AND HIGH THROUGHPUT SCREENING, NATURAL PRODUCTS, COMPUTER–ASSISTED DRUG DESIGN, STRUCTURE–BASED DRUG DESIGN, MECHANISM OF ACTION IDENTIFICATION, AND PATHWAY MODELLING. FURTHERMORE, STATE–OF THE ART "OMICS" TECHNOLOGIES ARE DESCRIBED AND CURRENTLY STUDIED ENZYMATIC DRUG TARGETS ARE DISCUSSED. MATHEMATICAL, SYSTEMS BIOLOGY–BASED APPROACHES ARE INTRODUCED AS NEW METHODOLOGIES FOR DISSECTING COMPLEX ASPECTS OF PATHOGEN SURVIVAL MECHANISMS AND FOR TARGET IDENTIFICATION. IN ADDITION, RECENTLY DEVELOPED ANTI–PARASITIC AGENTS TARGETING PARTICULAR PATHWAYS, WHICH SERVE AS LEAD COMPOUNDS FOR FURTHER DRUG DEVELOPMENT, ARE PRESENTED.

Críticas: "In summary, this book illustrates why it is extremely beneficial to 1) precisely understand the biology of a host-parasite unit and 2) combine a set of powerful alternative approaches for drug development as well as target identification and validation. In his foreword, Graham Coombs recommends that more experienced scientists should be encouraging those in the early stages of their career to remember appropriate past work, read books and not to forget the basic biology when applying novel approaches. I fully agree. Read this book" Prof. Dr. Marcel Deponte, Technische Universit-t Kaiserslautern, ChemMedchem, Sept 2017

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Título: Comprehensive Analysis of Parasite Biology: ...
Editorial: John Wiley and Sons Ltd
Año de publicación: 2016
Encuadernación: Hardback
Condición del libro: New
Edición: 1. Auflage.

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Sylke Müller (editor), Rachel Cerdan (editor), Ovidiu Radulescu (editor)
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Descripción Wiley 2016-08-31, Weinheim, 2016. hardback. Condición: New. Nº de ref. del artículo: 9783527339044

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Descripción Wiley VCH, 2016. HRD. Condición: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Nº de ref. del artículo: FW-9783527339044

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Descripción Wiley VCH 2016-08-17, 2016. Condición: New. Brand new book, sourced directly from publisher. Dispatch time is 4-5 working days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely. Nº de ref. del artículo: NU-LBR-01893507

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Sylke Müller; Rachel Cerdan; Ovidiu Radulescu; Ewelina Guca; Paul M. Selzer (Intervet Innovation GmbH, Schwabenheim, Germany)
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Descripción Condición: New. Publisher/Verlag: Wiley-VCH | From Metabolism to Drug Discovery | Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented. | Discovering the mechanism of action of novel compounds that target unicellular eucaryotic parasitesContribution of Natural Products to drug discovery in tropical diseasesIsoxazolines as effective ectoparasiticidesTrypanosomal Cysteine Proteases: Target Validation and Drug Design StrategiesPotential of pyrimidine metabolism for antitrypanosomal drug discoveryThe Kennedy pathways for phospholipid biosynthesis in PlasmodiumImmunophilins as possible drug targetsAutophagy in Plasmodium/invasion of PlasmodiumThe glideosome: the locomotive complex behind gliding motility and invasionTurnover of glycosomes in trypanosomes. Perspectives for drug discoveryN-myristoyltransferase as a target for Drug Discovery in MalariaIntermediary carbon metabolism of Plasmodium revisitedThe role of metabolomics in antiparasitic drug discoveryMethods to investigate system biology in TrypanosomaThe importance of targeting lipid metabolism in parasites for drug discoveryEpigenetic gene regulation: a key to development and survival of malaria parasitesEmerging importance of t-RNA synthetases as anti-malarial drug targetsUnderstanding protozoan parasite metabolism and identifying drug targets through flux balance analysisAttacking blood-borne parasites with mathematicsKinetic modeling of metabolism and drug target identification in ApicomplexaAntiparasitics from algaeMechanisms regulating transcription in Plasmodium falciparum as targets for novel antimalarial drugs | Format: Hardback | Language/Sprache: english | 1346 gr | 250x178x32 mm | 548 pp. Nº de ref. del artículo: K9783527339044

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Publicado por Wiley-Blackwell (2016)
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Descripción Wiley-Blackwell, 2016. Hardcover. Condición: New. Never used!. Nº de ref. del artículo: P113527339043

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Sylke Müller
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Descripción Wiley VCH Verlag Gmbh Sep 2016, 2016. Buch. Condición: Neu. Neuware - Dieses Buch, geschrieben von Fachexperten auf dem Gebiet, fasst den aktuellen Stand der Wissenschaft im Hinblick auf phänotypische und zielorientierte Ansätze der Entwicklung von Arzneistoffen gegen pathogene Protozoen zusammen. Der Schwerpunkt liegt dabei vor allem auf virtuellen Substanzen und dem Hochdurchsatz-Screening, auf Naturprodukten, dem computergestützten Design von Arzneistoffen, dem strukturgestützten Design von Arzneistoffen, der Identifizierung von Wirkmechanismen und dem Pathway-Modelling. Weiterhin werden moderne 'omik'-Technologien sowie enzymatische Drug Targets erörtert. Mathematische, auf der Systembiologie basierende Ansätze werden als neue Methoden für die Auflösung komplexer Mechanismen, die Pathogene überleben lassen, und für die Target-Identifizierung vorgestellt. Präsentiert werden darüber hinaus neu entwickelte Wirkstoffe, die über bestimmte Pathways Parasiten abtöten und als Leitsubstanzen für weitere Arzneimittelentwicklungen dienen. Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art 'omics' technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented. 548 pp. Englisch. Nº de ref. del artículo: 9783527339044

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Sylke Müller
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Descripción Wiley VCH Verlag Gmbh Sep 2016, 2016. Buch. Condición: Neu. Neuware - Dieses Buch, geschrieben von Fachexperten auf dem Gebiet, fasst den aktuellen Stand der Wissenschaft im Hinblick auf phänotypische und zielorientierte Ansätze der Entwicklung von Arzneistoffen gegen pathogene Protozoen zusammen. Der Schwerpunkt liegt dabei vor allem auf virtuellen Substanzen und dem Hochdurchsatz-Screening, auf Naturprodukten, dem computergestützten Design von Arzneistoffen, dem strukturgestützten Design von Arzneistoffen, der Identifizierung von Wirkmechanismen und dem Pathway-Modelling. Weiterhin werden moderne 'omik'-Technologien sowie enzymatische Drug Targets erörtert. Mathematische, auf der Systembiologie basierende Ansätze werden als neue Methoden für die Auflösung komplexer Mechanismen, die Pathogene überleben lassen, und für die Target-Identifizierung vorgestellt. Präsentiert werden darüber hinaus neu entwickelte Wirkstoffe, die über bestimmte Pathways Parasiten abtöten und als Leitsubstanzen für weitere Arzneimittelentwicklungen dienen. Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art 'omics' technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented. 548 pp. Englisch. Nº de ref. del artículo: 9783527339044

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M. Ller, Sylke
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Descripción 2016. HRD. Condición: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Nº de ref. del artículo: KS-9783527339044

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Müller, Sylke/ Cerdan, Rachel/ Radulescu, Ovidiu/ Selzer, Paul M. (Editor)/ Selzer, Paul M.
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Descripción Vch Pub, 2016. Hardcover. Condición: Brand New. 1st edition. 576 pages. 9.75x7.00x1.50 inches. In Stock. Nº de ref. del artículo: z-3527339043

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