SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS: Phase Behavior and Click Chemistry of Multi-Responsive Polymeric Microgel Dispersions - Tapa blanda

Meng, Zhiyong

 
9783838387109: SELF-ASSEMBLY AND CHEMO-LIGATION OF POLYMERIC RESPONSIVE MICROGELS: Phase Behavior and Click Chemistry of Multi-Responsive Polymeric Microgel Dispersions
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ISBN 10: 3838387104 ISBN 13: 9783838387109
Editorial: LAP LAMBERT Academic Publishing, 2010

Sinopsis

Microgels are sub-micron to micron-size polymeric networks confined in limited space swollen by a good solvent, also called hydrogel microparticles or microspheres if swollen in water. Among all microgels investigated nowadays, poly(N-isopropylacrylamide), pNIPAm, microgels are one of the most extensively studied microgel particles due to their volume phase transition (VPT) at lower critical solution temperature (LCST). By incorporation of pH-responsive monomer, acrylic acid (AAc), copolymeric pNIPAm-AAc microgels further demonstrate multi-responsivity to temperature, pH, and ionic strength. A temperature-programmed polymerization protocol is proposed for the synthesis of large pNIPAm-AAc microgel particles with a hydrodynamic diameter of 2~5 ?m. Futhermore, to observe the phase behavior of pNIPAm-AAc microgel dispersions, pNIPAm-AAc dispersions at various pH values and concentrations were allowed to age and undergo phase transition in closed system. Finally, the Cu(I)-catalyzed azide-terminal alkyne 1,3-dipolar cycloaddition, also called Sharpless-Meldal ?click? reaction, is used to functionalize pNIPAm-AAc microgel particles for microgel bioconjugation and medical applications.

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Reseña del editor

Microgels are sub-micron to micron-size polymeric networks confined in limited space swollen by a good solvent, also called hydrogel microparticles or microspheres if swollen in water. Among all microgels investigated nowadays, poly(N-isopropylacrylamide), pNIPAm, microgels are one of the most extensively studied microgel particles due to their volume phase transition (VPT) at lower critical solution temperature (LCST). By incorporation of pH-responsive monomer, acrylic acid (AAc), copolymeric pNIPAm-AAc microgels further demonstrate multi-responsivity to temperature, pH, and ionic strength. A temperature-programmed polymerization protocol is proposed for the synthesis of large pNIPAm-AAc microgel particles with a hydrodynamic diameter of 2~5 μm. Futhermore, to observe the phase behavior of pNIPAm-AAc microgel dispersions, pNIPAm-AAc dispersions at various pH values and concentrations were allowed to age and undergo phase transition in closed system. Finally, the Cu(I)-catalyzed azide-terminal alkyne 1,3-dipolar cycloaddition, also called Sharpless-Meldal "click" reaction, is used to functionalize pNIPAm-AAc microgel particles for microgel bioconjugation and medical applications.

Biografía del autor

Zhiyong Meng, PhD: He studied phase behavior and click chemistry of polymeric microgels at Georgia Tech. His research interests cover polymer synthesis, multi-responsive hydrogels/microgels, aggregation of colloidal particles, and microfluidics. He is currently a postdoctoral associate working with Professor Menachem Elimelech at Yale University.

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Editorial
LAP LAMBERT Academic Publishing
Año de publicación
2010
Idioma
Inglés
ISBN 10 
3838387104
ISBN 13 
9783838387109
Encuadernación
Tapa blanda
Número de páginas
172
Contacto del fabricante
no disponible
Persona responsable
no disponible