Development of Carvedilol Phosphate sustained release tablet: Anti-hypertensive agent:Carvedilol phosphate

 
9783659228452: Development of Carvedilol Phosphate sustained release tablet: Anti-hypertensive agent:Carvedilol phosphate

The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS > PEG 6000 > Poloxamer 188.

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About the Author:

Uttom Kumar completed his M. Pharm. from the Department of Pharmaceutical Technology, University of Dhaka, Bangladesh. He conducted his thesis under the supervision of Prof. Dr. A. S. Shamsur Rouf, a renowned scientist. Currently Uttom is a member of Dr. Rouf’s research lab where Mr. Harun-Or-Rashid is an associate researcher.

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Uttom Kumar
Editorial: LAP Lambert Academic Publishing 2012-08-29 (2012)
ISBN 10: 3659228451 ISBN 13: 9783659228452
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Descripción LAP Lambert Academic Publishing 2012-08-29, 2012. paperback. Estado de conservación: New. Nº de ref. de la librería 9783659228452

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Kumar, Uttom
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Descripción LAP Lambert Academic Publishing, 2016. Paperback. Estado de conservación: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Nº de ref. de la librería ria9783659228452_lsuk

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Descripción Estado de conservación: New. Publisher/Verlag: LAP Lambert Academic Publishing | Anti-hypertensive agent:Carvedilol phosphate | The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS PEG 6000 Poloxamer 188. | Format: Paperback | Language/Sprache: english | 156 pp. Nº de ref. de la librería K9783659228452

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Uttom Kumar; MR Harun-Or-Rashid; A. S. Shamsur Rouf
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Descripción LAP Lambert Academic Publishing, 2012. Estado de conservación: New. This item is printed on demand for shipment within 3 working days. Nº de ref. de la librería LP9783659228452

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Descripción LAP Lambert Academic Publishing, 2012. PAP. Estado de conservación: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Nº de ref. de la librería IQ-9783659228452

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Uttom Kumar
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Descripción LAP Lambert Academic Publishing Dez 2016, 2016. Taschenbuch. Estado de conservación: Neu. Neuware - The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS PEG 6000 Poloxamer 188. 156 pp. Englisch. Nº de ref. de la librería 9783659228452

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Uttom Kumar
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Descripción LAP Lambert Academic Publishing Dez 2016, 2016. Taschenbuch. Estado de conservación: Neu. Neuware - The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS PEG 6000 Poloxamer 188. 156 pp. Englisch. Nº de ref. de la librería 9783659228452

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Uttom Kumar, MR Harun-Or-Rashid, Dr A S Shamsur Rouf
Editorial: LAP Lambert Academic Publishing, Germany (2016)
ISBN 10: 3659228451 ISBN 13: 9783659228452
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Descripción LAP Lambert Academic Publishing, Germany, 2016. Paperback. Estado de conservación: New. Aufl.. Language: English . Brand New Book ***** Print on Demand *****.The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS > PEG 6000 > Poloxamer 188. Nº de ref. de la librería AAV9783659228452

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Uttom Kumar
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Descripción LAP Lambert Academic Publishing Dez 2016, 2016. Taschenbuch. Estado de conservación: Neu. This item is printed on demand - Print on Demand Neuware - The objective of the present study was to design and evaluate sustained release tablet of Carvedilol Phosphate employing semi-synthetic polymers Methocel K4M CR and Methocel K15M CR as release retarding materials. Two sets of formulations prepared where first set of five formulations (F1-F5) contained variable ratios of polymers and second set of ten formulations (F6-F15) contained variable ratios of three different dissolution enhancers, namely Sodium Lauryl Sulfate (SLS), PEG 6000 and Poloxamer 188. An increase in release rate of the drug from the tablet matrix was observed by decreasing the polymers percentage, specifically Methocel K15 M CR. The tablet matrices prepared using SLS showed a higher dissolution rate and gave a dissolution profile that was comparable to the theoretical sustained release needed for once daily administration of Carvedilol Phosphate. The order of dissolution enhancing power was: SLS PEG 6000 Poloxamer 188. 156 pp. Englisch. Nº de ref. de la librería 9783659228452

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