Cancer Immunology and Immunotherapy (Current Topics in Microbiology and Immunology)

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9783642267888: Cancer Immunology and Immunotherapy (Current Topics in Microbiology and Immunology)

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

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The recent FDA approval of Provenge® as the first therapeutic cancer vaccine together with the recent demonstration that Ipilimumab®, a monoclonal antibody that blocks the negative immune checkpoint cytotoxic T lymphocyte associated antigen-4, prolongs patient survival are major achievements that usher in a new era of cancer immunotherapy. These “first-in-class” treatments reflect the substantive progress that basic and translational scientists have made towards understanding the mechanisms underlying protective tumor immunity in cancer patients Immunotherapies were first explored at the turn of the twentieth century, but the crafting of potent treatments required more detailed knowledge of how the immune system responds to cancer. Advances in genetic, cellular, and biochemical technologies have begun to yield this critical information, focusing attention on immune recognition, regulation, and escape. Indeed, the dynamic interplay of these processes in the tumor microenvironment is now recognized to play a decisive role in determining disease outcome. This volume highlights the rapid progress and breadth of research in cancer immunology, and provides a framework for anticipating many more clinical successes in cancer immunotherapy.

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From the reviews:

“This book comprises 13 reviews, contributed by members of a cross-section of groups working in the ... field of cancer immunology. ... this book is at its best when considering small and apparently discrete topics ­­– its strength comes from being able to read all of these ideas on one place. ... Overall, this book gives a thorough and detailed overview of the current state of basic and translational research into cancer immunology ... . It’s probably most appropriate for researchers ... .”­­­ (Victoria Lawson, Immunology News, November, 2011)

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ISBN 10: 3642267882 ISBN 13: 9783642267888
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Descripción Springer Berlin Heidelberg 2013-05-28, Berlin, 2013. paperback. Estado de conservación: New. Nº de ref. de la librería 9783642267888

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Descripción Springer-Verlag Berlin and Heidelberg GmbH & Co. KG. Paperback. Estado de conservación: new. BRAND NEW, Cancer Immunology and Immunotherapy, Glenn Dranoff, The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment. Nº de ref. de la librería B9783642267888

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Descripción Springer, 2013. Estado de conservación: New. Cancer Immunotherapy discusses tumor-immune interactions in several human cancers. The text proposes an integrated scheme of the impact of local immune reactions on clinical outcome, and illustrates various aspects of this complexity. Editor(s): Dranoff, Glenn. Series: Current Topics in Microbiology and Immunology. Num Pages: 306 pages, biography. BIC Classification: MJCL; MJCM. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 18. Weight in Grams: 492. . 2013. 2011th Edition. Paperback. . . . . . Nº de ref. de la librería V9783642267888

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Descripción Paperback. Estado de conservación: New. Not Signed; The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human ca. book. Nº de ref. de la librería ria9783642267888_rkm

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Descripción Springer. Estado de conservación: New. Cancer Immunotherapy discusses tumor-immune interactions in several human cancers. The text proposes an integrated scheme of the impact of local immune reactions on clinical outcome, and illustrates various aspects of this complexity. Editor(s): Dranoff, Glenn. Series: Current Topics in Microbiology and Immunology. Num Pages: 306 pages, biography. BIC Classification: MJCL; MJCM. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 18. Weight in Grams: 492. . 2013. 2011th Edition. Paperback. . . . . Books ship from the US and Ireland. Nº de ref. de la librería V9783642267888

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Descripción Springer, 2013. Estado de conservación: New. Nº de ref. de la librería GH9783642267888

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Descripción Springer-Verlag Berlin and Heidelberg GmbH and Co. KG, 2013. PAP. Estado de conservación: New. New Book. Delivered from our US warehouse in 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND.Established seller since 2000. Nº de ref. de la librería IP-9783642267888

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Glenn Dranoff
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