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“This book comprises 13 reviews, contributed by members of a cross-section of groups working in the ... field of cancer immunology. ... this book is at its best when considering small and apparently discrete topics – its strength comes from being able to read all of these ideas on one place. ... Overall, this book gives a thorough and detailed overview of the current state of basic and translational research into cancer immunology ... . It’s probably most appropriate for researchers ... .” (Victoria Lawson, Immunology News, November, 2011)The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
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- EditorialSpringer
- Año de publicación2011
- ISBN 10 3642141358
- ISBN 13 9783642141355
- EncuadernaciónTapa dura
- Número de páginas320
- EditorDranoff Glenn
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Cancer Immunology and Immunotherapy (Current Topics in Microbiology and Immunology) [Hardcover ]
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Cancer Immunology and Immunotherapy (Current Topics in Microbiology and Immunology, 344)
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Cancer Immunology and Immunotherapy
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Descripción Condición: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tu. Nº de ref. del artículo: 5050410
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Cancer Immunology and Immunotherapy
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Descripción Buch. Condición: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment. 320 pp. Englisch. Nº de ref. del artículo: 9783642141355
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Cancer Immunology and Immunotherapy
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Cancer Immunology and Immunotherapy
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Descripción Buch. Condición: Neu. Druck auf Anfrage Neuware - Printed after ordering - The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment. Nº de ref. del artículo: 9783642141355
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