Post-Structural Genomics: Correlate Protein Sequence, Structure, and Function - Tapa blanda

Post-Structural Genomics : Correlate Protein Sequence, Structure, and Function

Taschenbuch. Condición: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - One of the goals the post-genomic era is to useprotein sequence and structure data to learn aboutthe function of these proteins in normal and diseasestates. In the omics era, computational methodsconstitute a valuable tool, because they can easilyprocess large amounts of data and provide useful andinstant information relevant in biomedical research.This book described using computational approaches tostudy the effects of genetic mutations in proteins,with the general aim of correlating protein sequence,structure, and function. Our works focus onidentifying whether genotype/phenotype relationshipcan be learned from protein sequence and structuralinformation, whether protein structure predictionmethods are accurate enough to provide usefulinformation when the experimental structures are notavailable, and finally to combine this information topredict and understand the effect of mutations onclinical phenotype and drug responses. The approachesdeveloped in this work enable a systematic,comprehensive, and quantitative analysis ofdisease-related mutations and establish a paradigm tostudy genotype/phenotype correlations. Nº de ref. del artículo: 9783639113167

Contactar al vendedor