Stem Cell Proliferation and Differentiation: A Multitype Branching Process Model: 76 (Lecture Notes in Biomathematics, 76) - Tapa blanda

Alan S. Perelson, Catherine A. Macken

 
9783540501831: Stem Cell Proliferation and Differentiation: A Multitype Branching Process Model: 76 (Lecture Notes in Biomathematics, 76)
Tapa blanda
ISBN 10: 3540501835 ISBN 13: 9783540501831
Editorial: Springer Berlin Heidelberg, 1988

Sinopsis

The body contains many cellular systems that require the continuous production of new, fully functional, differentiated cells to replace cells lacking or having limited self-renewal capabilities that die or are damaged during the lifetime of an individual. Such systems include the epidermis, the epithelial lining of the gut, and the blood. For example, erythrocytes (red blood cells) lack nuclei and thus are incapable of self-replication. They have a life span in the circulation of about 120 days. Mature granulocytes, which also lack proliferative capacity, have a much shorter life span - typically 12 hours, though this may be reduced to only two or three hours in times of serious tissue infection. Perhaps a more familiar example is the outermost layer of the skin. This layer is composed of fully mature, dead epidermal cells that must be replaced by the descendants of stem cells lodged in lower layers of the epidermis (cf. Alberts et al. , 1983). In total, to supply the normal steady-state demands of cells, an average human must produce approximately 3. 7 x 1011 cells a day throughout life (Dexter and Spooncer, 1987). Common to each of these cellular systems is a primitive (undifferentiated) stem cell which replenishes cells through the production of offspring, some of which proliferate and gradually differentiate until mature, fully functional cells are produced.

"Sinopsis" puede pertenecer a otra edición de este libro.

Reseña del editor

The body contains many cellular systems that require the continuous production of new, fully functional, differentiated cells to replace cells lacking or having limited self-renewal capabilities that die or are damaged during the lifetime of an individual. Such systems include the epidermis, the epithelial lining of the gut, and the blood. For example, erythrocytes (red blood cells) lack nuclei and thus are incapable of self-replication. They have a life span in the circulation of about 120 days. Mature granulocytes, which also lack proliferative capacity, have a much shorter life span - typically 12 hours, though this may be reduced to only two or three hours in times of serious tissue infection. Perhaps a more familiar example is the outermost layer of the skin. This layer is composed of fully mature, dead epidermal cells that must be replaced by the descendants of stem cells lodged in lower layers of the epidermis (cf. Alberts et al. , 1983). In total, to supply the normal steady-state demands of cells, an average human must produce approximately 3. 7 x 1011 cells a day throughout life (Dexter and Spooncer, 1987). Common to each of these cellular systems is a primitive (undifferentiated) stem cell which replenishes cells through the production of offspring, some of which proliferate and gradually differentiate until mature, fully functional cells are produced.

Reseña del editor

The book develops a model for stem cell proliferation and differentiation. It is a substantial generalization of the famous Till and McCulloch model. It describes the growth of stem cells in culture and the formation of both progenitor cells and end cells. The book contains a biologically realistic application of branching processes and should be of interest to mathematics students and teachers of stochastic process courses.

"Sobre este título" puede pertenecer a otra edición de este libro.

Editorial
Springer Berlin Heidelberg
Año de publicación
1988
Idioma
Inglés
ISBN 10 
3540501835
ISBN 13 
9783540501831
Encuadernación
Tapa blanda
Número de páginas
128
Contacto del fabricante
no disponible
Persona responsable
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Alemania

Otras ediciones populares con el mismo título

9780387501833: Stem Cell Proliferation and Differentiation (Lecture Notes in Biomathematics)

Edición Destacada

ISBN 10:  0387501835 ISBN 13:  9780387501833
Editorial: Springer Verlag, 1988
Tapa blanda