Pharmacokinetic-Pharmacodynamic Modeling and Simulation

3,67 valoración promedio
( 3 valoraciones por Goodreads )
 
9781441994844: Pharmacokinetic-Pharmacodynamic Modeling and Simulation

This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.

"Sinopsis" puede pertenecer a otra edición de este libro.

From the Back Cover:

Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been applauded by students and teachers for its readability and exposition of complex statistical topics. Using a building block approach, the text starts with linear regression, nonlinear regression, and variance models at the individual level and then moves to population-level models with linear and nonlinear mixed effects models.  Particular emphasis is made highlighting relationships between the model types and how the models build upon one another. 

With the second edition, new chapters on generalized nonlinear mixed effects models and Bayesian models are presented, along with an extensive chapter on simulation.  In addition, many chapters have been updated to reflect recent developments.  The theory behind the methods is illustrated using real data from the literature and from the author's experiences in drug development.  Data are analyzed using a variety of software, including NONMEM, SAS, SAAM II, and WinBUGS.  A key component of the book is to show how models are developed using an acceptance-rejection paradigm with the ultimate goal of using models to explain data, summarize complex experiments, and use simulation to answer "what-if" questions. Scientists and statisticians outside the pharmaceutical sciences will find the book invaluable as a reference for applied modeling and simulation.

About the Author:

Peter Bonate has 16 years industrial experience, 13 years as a clinical pharmacologist/pharmacokineticist and three years in drug metabolism and bioanalysis. He is currently a Director in the Clinical Pharmacology, Modeling, and Simulation department at GlaxoSmithKline in the oncology and rare diseases therapeutic areas.   He has worked at Genzyme, Hoechst Marion Roussel, Eli Lilly, and Quintiles.  He received his PhD in 1996 from Indiana University in Medical Neurobiology with an emphasis on the pharmacokinetics of drugs of abuse.  He received an MS in statistics from the University of Idaho and an MS in Pharmacology from Washington State University, both in 1990.  In 2003 he was elected a Fellow of the American College of Clinical Pharmacology and in 2007 was elected a fellow of the American Association of Pharmaceutical Scientists (AAPS).  He was founder of the Modeling and Simulation focus group, has served as chair of the population pharmacokinetics focus group, and was the Clinical Pharmacology and Translational Research Section Chair within AAPS.  He has served or currently serves on the editorial boards for the Journal of Clinical Pharmacology, Pharmaceutical Research, Journal of Pharmacokinetics and Pharmacodynamics, and The AAPS Journal.  He has more than 50 publications in the field of pharmacokinetics and clinical pharmacology, is co-editor of the 3-volume series Pharmacokinetics in Drug Development published by AAPS Press in 2004 and 2011, and is author of the book Pharmacokinetic-Pharmacodynamic Modeling and Simulation  published by Springer in 2006.  In 2010, he became an Adjunct Assistant Professor at the Indiana University School of Medicine and the University of North Carolina, Chapel Hill.

"Sobre este título" puede pertenecer a otra edición de este libro.

Comprar nuevo Ver libro

Gastos de envío: EUR 10,23
De Reino Unido a Estados Unidos de America

Destinos, gastos y plazos de envío

Añadir al carrito

Los mejores resultados en AbeBooks

1.

Peter L. Bonate
Editorial: Springer-Verlag New York Inc. (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Cantidad: 2
Librería
Books2Anywhere
(Fairford, GLOS, Reino Unido)
Valoración
[?]

Descripción Springer-Verlag New York Inc., 2011. HRD. Estado de conservación: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Nº de ref. de la librería GB-9781441994844

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 127,36
Convertir moneda

Añadir al carrito

Gastos de envío: EUR 10,23
De Reino Unido a Estados Unidos de America
Destinos, gastos y plazos de envío

2.

Peter L. Bonate
Editorial: Springer-Verlag New York Inc., United States (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Tapa dura Cantidad: 1
Librería
The Book Depository
(London, Reino Unido)
Valoración
[?]

Descripción Springer-Verlag New York Inc., United States, 2011. Hardback. Estado de conservación: New. 2nd ed. 2011. Language: English . Brand New Book. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. Nº de ref. de la librería AAZ9781441994844

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 140,26
Convertir moneda

Añadir al carrito

Gastos de envío: GRATIS
De Reino Unido a Estados Unidos de America
Destinos, gastos y plazos de envío

3.

Bonate, Peter L.; Bonate, Peter L., Ph.d.
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Cantidad: 1
Librería
GreatBookPrices
(Columbia, MD, Estados Unidos de America)
Valoración
[?]

Descripción Estado de conservación: New. Nº de ref. de la librería 12656256-n

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 138,22
Convertir moneda

Añadir al carrito

Gastos de envío: EUR 2,24
A Estados Unidos de America
Destinos, gastos y plazos de envío

4.

Peter L. Bonate
Editorial: Springer-Verlag New York Inc., United States (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Tapa dura Cantidad: 1
Librería
The Book Depository US
(London, Reino Unido)
Valoración
[?]

Descripción Springer-Verlag New York Inc., United States, 2011. Hardback. Estado de conservación: New. 2nd ed. 2011. Language: English . Brand New Book. This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. Nº de ref. de la librería AAZ9781441994844

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 140,54
Convertir moneda

Añadir al carrito

Gastos de envío: GRATIS
De Reino Unido a Estados Unidos de America
Destinos, gastos y plazos de envío

5.

Peter L. Bonate
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Cantidad: 2
Librería
Speedy Hen LLC
(Sunrise, FL, Estados Unidos de America)
Valoración
[?]

Descripción Estado de conservación: New. Bookseller Inventory # ST144199484X. Nº de ref. de la librería ST144199484X

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 140,55
Convertir moneda

Añadir al carrito

Gastos de envío: GRATIS
A Estados Unidos de America
Destinos, gastos y plazos de envío

6.

Peter L. Bonate
Editorial: Springer US 2011-07-01, New York |London (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Tapa dura Cantidad: 1
Librería
Blackwell's
(Oxford, OX, Reino Unido)
Valoración
[?]

Descripción Springer US 2011-07-01, New York |London, 2011. hardback. Estado de conservación: New. Nº de ref. de la librería 9781441994844

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 138,47
Convertir moneda

Añadir al carrito

Gastos de envío: EUR 6,82
De Reino Unido a Estados Unidos de America
Destinos, gastos y plazos de envío

7.

Peter L. Bonate
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Cantidad: 2
Librería
Speedy Hen
(London, Reino Unido)
Valoración
[?]

Descripción Estado de conservación: New. Bookseller Inventory # ST144199484X. Nº de ref. de la librería ST144199484X

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 125,22
Convertir moneda

Añadir al carrito

Gastos de envío: EUR 21,61
De Reino Unido a Estados Unidos de America
Destinos, gastos y plazos de envío

8.

Bonate, Peter L.
Editorial: Springer (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Tapa dura Cantidad: 2
Librería
Murray Media
(North Miami Beach, FL, Estados Unidos de America)
Valoración
[?]

Descripción Springer, 2011. Hardcover. Estado de conservación: New. Never used!. Nº de ref. de la librería P11144199484X

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 151,11
Convertir moneda

Añadir al carrito

Gastos de envío: EUR 1,69
A Estados Unidos de America
Destinos, gastos y plazos de envío

9.

Peter L. Bonate
Editorial: Springer (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Tapa dura Cantidad: 1
Librería
Irish Booksellers
(Rumford, ME, Estados Unidos de America)
Valoración
[?]

Descripción Springer, 2011. Hardcover. Estado de conservación: New. book. Nº de ref. de la librería M144199484X

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 153,51
Convertir moneda

Añadir al carrito

Gastos de envío: GRATIS
A Estados Unidos de America
Destinos, gastos y plazos de envío

10.

Peter L. Bonate
Editorial: Springer 2011-07-02 (2011)
ISBN 10: 144199484X ISBN 13: 9781441994844
Nuevos Cantidad: 3
Librería
Chiron Media
(Wallingford, Reino Unido)
Valoración
[?]

Descripción Springer 2011-07-02, 2011. Estado de conservación: New. Brand new book, sourced directly from publisher. Dispatch time is 24-48 hours from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely. Nº de ref. de la librería NU-LBR-00946884

Más información sobre esta librería | Hacer una pregunta a la librería

Comprar nuevo
EUR 153,17
Convertir moneda

Añadir al carrito

Gastos de envío: EUR 3,40
De Reino Unido a Estados Unidos de America
Destinos, gastos y plazos de envío

Existen otras copia(s) de este libro

Ver todos los resultados de su búsqueda