Kapitel: Gentamicin, Rifaximin, Aciclovir, Metronidazol, Chloramphenicol, Lysozym, Sulfamerazin, Chlortetracyclin, Oxytetracyclin, Podophyllotoxin, Mupirocin, Amikacin, Imiquimod, Sulfanilamid, Silbersulfadiazin, Penciclovir, Bacitracin, Tyrothricin, Fusidinsaure, Inosin, Idoxuridin. Aus Wikipedia. Nicht dargestellt. Auszug: Chloramphenicol (INN) is a bacteriocidal antimicrobial. It is considered a prototypical broad-spectrum antibiotic, alongside the tetracyclines. Chloramphenicol is effective against a wide variety of Gram-positive and Gram-negative bacteria, including most anaerobic organisms. Due to resistance and safety concerns, it is no longer a first-line agent for any indication in developed nations, although it is sometimes used topically for eye infections; nevertheless, the global problem of advancing bacterial resistance to newer drugs has led to renewed interest in its use. In low-income countries, chloramphenicol is still widely used because it is exceedingly inexpensive and readily available. The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two distinct forms: bone marrow suppression, which is a direct toxic effect of the drug and is usually reversible, and aplastic anemia, which is idiosyncratic (rare, unpredictable, and unrelated to dose) and generally fatal. Because it functions by inhibiting bacterial protein synthesis, chloramphenicol has a very broad spectrum of activity: it is active against Gram-positive bacteria (including most strains of MRSA), Gram-negative bacteria and anaerobes. It is not active against Pseudomonas aeruginosa, Chlamydiae, or Enterobacter species. It has some activity against Burkholderia pseudomallei, but is no longer routinely used to treat infections caused by this organism (it has been superseded by ceftazidime and meropenem). In the West, chloramphenicol is mostly restricted to topical uses because of the wor...http: //booksllc.net/?l=d
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