Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 25. Chapters: Tobacco, Bupropion, Ibogaine, Dextromethorphan, Curare, Pancuronium bromide, 18-Methoxycoronaridine, Mecamylamine, Vanoxerine, Trimetaphan camsilate, 2-Methoxyethyl-18-methoxycoronaridinate, 18-Methylaminocoronaridine, Nicotinic antagonist, Alpha-Bungarotoxin, Pentolinium. Excerpt: Bupropion ( -pee-ahn; marketed as Wellbutrin, Zyban, Voxra, Budeprion, or Aplenzin; formerly known as amfebutamone) is an atypical antidepressant and smoking cessation aid. The drug is a non-tricyclic antidepressant and differs from most commonly prescribed antidepressants such as SSRIs, as its primary pharmacological action is thought to be norepinephrine-dopamine reuptake inhibition. It binds selectively to the dopamine transporter, but its behavioural effects have often been attributed to its inhibition of norepinephrine reuptake. It also acts as a nicotinic acetylcholine receptor antagonist. Bupropion belongs to the chemical class of aminoketones and is similar in structure to stimulants cathinone and diethylpropion, and to phenethylamines in general. Initially researched and marketed as an antidepressant, bupropion was subsequently found to be effective as a smoking cessation aid. With over 20 million retail prescriptions in 2007, it was the fourth-most prescribed antidepressant in the United States retail market after sertraline, escitalopram, and fluoxetine. Bupropion lowers seizure threshold, and its potential to cause seizures has been widely publicized. However, at the recommended dose the risk of seizures is comparable to that observed for other antidepressants. Bupropion is an effective antidepressant on its own but it is particularly popular as an add-on medication in the cases of incomplete response to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. In contrast to many other antidepressants, bupr...
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