Mechanics of Motor Protein and the Cytoskeleton - Tapa dura

This text is for biology, biochemistry and chemistry students who want to learn about the principles of protein mechanics and how it applies to the morphology and motility of cells. Understanding how motors and the cytoskeleton operate requires mechanical concepts such as force, elasticity and damping. Introductory physics textbooks address these concepts, yet they are concerned primarily with macroscopic systems, whose motions are qualitatively different from the highly damped, diffusive motion of individual molecules; this book provides a physical foundation for molecular mechanics. Part I explains how small particles like proteins respond to mechanical, thermal, and chemical forces, Part II focuses on cytoskeletal filaments, and Part III focuses on motor proteins. The treatments are unified in the respect that they are organized around principles rather than proteins: chapters are centered on topics such as structure, chemistry, and mechanics, and different filaments or motors are discussed together.

JONATHON HOWARD is Professor of Physiology and Biophysics at the University of Washington in Seattle.