The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3e

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9780750673600: The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3e

110 of the world's foremost authorities explore the latest advances in molecular and cellular neurobiology and molecular neurogenetics and their implications for the development of pharmacologic or gene therapy for patients with genetic diseases of the nervous system. The 3rd Edition features a new section on psychiatric diseases, 26 additional new chapters, and an even stronger clinical focus, offering practical guidance on a full range of diseases and the roles that molecular biology and genetics play in their diagnosis and management.the latest advances in molecular research.

  • Includes a brand-new section on Psychiatric Diseases, edited by Dr. Eric J. Nestler, that features chapters on Challenges in Psychiatric Genetics · Depression · Bipolar Disorders · Schizophrenia · Obsessive-Compulsive Disorder and Tourette's Syndrome · Molecular and Genetic Basis of Addiction · and Autism.
  • Offers two new chapters on Degenerative Diseases and Protein Processing and Prion Diseases, authored by Dr. Stanley B. Prusiner, winner of the 1997 Nobel Prize in Medicine for his research defining the molecular and genetic basis of the spongiform encephalopathies and the expression of the prion gene under both physiologic and pathologic conditions.
  • Incorporates new data and insights from the analysis and sequencing of the human genome into three new chapters on The Human Genome Project and Neurological Disease, Gene Therapy, and Ethical Issues in Diagnosis and Therapy.
  • Features 21 additional new chapters: Animal Models (mice, worms, flies) · Gene Targeting/Gene Mapping · Genotype/Phenotype Correlations · Mitochondrial Disorders Due to Mutations in the Nuclear Genome · Mitochondria in Neurodegenerative Disorders · Lysosomal Membrane Disorders - LAMP-2 Deficiency · Alzheimer's Disease and Related Dementias · Movement Disorders · Neuronopathies · Limb Girdle Muscular Dystrophies · Congenital Myopathies · Hereditary Inclusion - Body Myopathies · Facioscapulohumeral Muscular Dystrophy · The Phakomatoses: Disorders of Skin and Brain · Disorder of Galactose Metabolism · Disorders of Glucose Transport · Congenital Disorders of Glycosylation · Disorders of Glutathione Metabolism · Friedreich Ataxia and Iron Metabolism · The Influence of Alpha Tocopherol, Caloric Restriction and Genes on Life Span · and A Neurologic Gene Map.

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About the Author:

Roger N. Rosenberg, MD holds the Abe (Brunky), Morris and William Zale Distinguished Chair and Professor of Neurology, University of Texas Southwestern Medical Center at Dallas. He served as Chair of the Department of Neurology from 1973- 1991. He is the founding Director of the NIH funded Alzheimer’s Disease Center at UT Southwestern and it has been funded through five consecutive competitive funding cycles since 1988 and will be funded through 2016 representing 27 years of continuous NIH Center funding. He is certified by the American Board of Psychiatry and Neurology. He served as Chief Resident in Neurology to H. Houston Merritt, MD, Neurological Institute, Columbia University Medical Center, New York, 1967-1968. He was a Post-Doctoral Research Fellow for Marshall Nirenberg, PhD, Laboratory of Biochemical Genetics, National Institutes of Health, 1968-1970.

Dr. Rosenberg has received important honors and awards including the prestigious UT Chancellor’s Discovery Lecture, invited by Chancellor Francisco Cigarroa for the Chancellor’s Council Meeting and Symposium, the University of Texas System, 2013. The Discovery Lecture was: “DNA Aß42 Vaccination as Therapy for Alzheimer’s Disease . He was awarded the World Federation of Neurology, 1st Science Medal for Scientific Achievements in Neurology and Neuroscience, presented at the World Congress of Neurology in Bangkok, Thailand in 2009.

He is an Honorary Member (Elected) of the American Neurological Association, 2006 and the American Academy of Neurology 1997.

He received the Nancy R. McCune Research Award of the Alzheimer’s Association (AWARE) (2005).

He was the Robert Wartenberg Lecturer of the American Academy of Neurology, 2000, and his lecture was “The Molecular and Genetic Basis of Alzheimer’s Disease .

He is an elected Honorary Member, Spanish Neurological Society, 1994. He was awarded the 1st Distinguished Neurology Alumnus Award of the Neurological Institute; Columbia University Medical Center; 1994.

He has been the Editor in Chief, JAMA Neurology (1997- present) and a member of the Editorial Board of JAMA (1997-present).

He was elected a Fellow, American Association for the Advancement of Science, February 1991

He was elected President of the American Academy of Neurology (1991-1993) and

1st Vice President of the American Neurological Association (1988-89). He received the Northwestern University Medical School Alumni Association Merit Award (1986).

In 2006, he published for the first time that a DNA A ß42 vaccine administered with the gene gun method into the skin of Alzheimer disease model mice can reduce Aß42 peptide levels in the brain by 50% with anti-A ß42 antibody of the IgG1/Th2 type which is known to be anti-inflammatory. He received in 2009 a US Patent as Inventor of “Amyloid ß Gene Vaccines . This DNA vaccine has the potential to be a safe and effective therapy to prevent Alzheimer disease.

He described Machado-Joseph disease (MJD), an autosomal dominant ataxia, with William Nyhan, M.D. Ph.D, in 1976, for the first time. MJD is now the most common autosomal domiant spinocerebellar ataxia world-wide.

Dr. Rosenberg has published over 270 original scientific papers, chapters, reviews and editorials. He is the founding editor and senior editor since 1993 for all five editions of “The Molecular and Genetic Basis of Neurological and Psychiatric Diseases .

Dr. Nestler is the Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A., Ph.D., and M.D. degrees, and psychiatry residency training, from Yale University. He served on the Yale faculty from 1987-2000, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. The goal of Dr. Nestler’s research is to better understand the molecular mechanisms of addiction and depression based on work in animal models, and to use this information to develop improved treatments of these disorders.

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