Biophysics: Searching for Principles

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9780691138916: Biophysics: Searching for Principles
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INTERACTIONS BETWEEN THE FIELDS OF PHYSICS AND BIOLOGY REACH BACK OVER A CENTURY, AND SOME OF THE MOST SIGNIFICANT DEVELOPMENTS IN BIOLOGY - FROM THE DISCOVERY OF DNAS STRUCTURE TO IMAGING OF THE HUMAN BRAIN - HAVE INVOLVED COLLABORATION ACROSS THIS DISCIPLINARY BOUNDARY. FOR A NEW GENERATION OF PHYSICISTS, THE PHENOMENA OF LIFE POSE EXCITING CHALLENGES TO PHYSICS ITSELF, AND BIOPHYSICS HAS EMERGED AS AN IMPORTANT SUBFIELD OF THIS DISCIPLINE. HERE, WILLIAM BIALEK PROVIDES THE FIRST GRADUATE-LEVEL INTRODUCTION TO BIOPHYSICS AIMED AT PHYSICS STUDENTS. BIALEK BEGINS BY EXPLORING HOW PHOTON COUNTING IN VISION OFFERS IMPORTANT LESSONS ABOUT THE OPPORTUNITIES FOR QUANTITATIVE, PHYSICS-STYLE EXPERIMENTS ON DIVERSE BIOLOGICAL PHENOMENA. HE DRAWS FROM THESE LESSONS THREE GENERAL PHYSICAL PRINCIPLES - THE IMPORTANCE OF NOISE, THE NEED TO UNDERSTAND THE EXTRAORDINARY PERFORMANCE OF LIVING SYSTEMS WITHOUT APPEALING TO FINELY TUNED PARAMETERS, AND THE CRITICAL ROLE OF THE REPRESENTATION AND FLOW OF INFORMATION IN THE BUSINESS OF LIFE. BIALEK THEN APPLIES THESE PRINCIPLES TO A BROAD RANGE OF PHENOMENA, INCLUDING THE CONTROL OF GENE EXPRESSION, PERCEPTION AND MEMORY, PROTEIN FOLDING, THE MECHANICS OF THE INNER EAR, THE DYNAMICS OF BIOCHEMICAL REACTIONS, AND PATTERN FORMATION IN DEVELOPING EMBRYOS. FEATURING NUMEROUS PROBLEMS AND EXERCISES THROUGHOUT, "BIOPHYSICS" EMPHASIZES THE UNIFYING POWER OF ABSTRACT PHYSICAL PRINCIPLES TO MOTIVATE NEW AND NOVEL EXPERIMENTS ON BIOLOGICAL SYSTEMS. IT COVERS A RANGE OF BIOLOGICAL PHENOMENA FROM THE PHYSICISTS PERSPECTIVE. IT FEATURES 200 PROBLEMS. IT IS DRAWS ON STATISTICAL MECHANICS, QUANTUM MECHANICS, AND RELATED MATHEMATICAL CONCEPTS. IT INCLUDES AN ANNOTATED BIBLIOGRAPHY AND DETAILED APPENDIXES. IT IS AN INSTRUCTORS MANUAL (AVAILABLE ONLY TO TEACHERS).

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Críticas:

William Bialek, Winner of the 2013 Swartz Prize for Theoretical and Computational Neuroscience, Society for Neuroscience "[T]he book goes beyond being a structured material for readers to learn about biophysics; it takes readers on an incredible journey in discovering fascinating ways in which biological phenomena can be viewed and studied. The technical adroitness and more importantly, the unique way of thinking about biological problems, in the reviewer's opinion, makes the book a must-read for any aspiring biophysicists."--Angie Ma, Contemporary Physics "[P]hysicists who are seeking an exciting intellectual path through the complexity of biology will deeply appreciate Bialek's clear vision of the big ideas and his expert guidance through their many applications."--Stephen J. Hagen, Physics Today "The book is well crafted, linking the historic work of the 'giants', e.g. Helmholtz with his seminal view of vision and hearing, with latest and trendy research, exemplified by the use of information theory in biology."--Robert Endres, Biological Physics Group Newsletter

Reseña del editor:

Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology--from the discovery of DNA's structure to imaging of the human brain--have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles--the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. * Covers a range of biological phenomena from the physicist's perspective * Features 200 problems * Draws on statistical mechanics, quantum mechanics, and related mathematical concepts * Includes an annotated bibliography and detailed appendixes * Instructor's manual (available only to teachers)

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