Phage Therapy - Part B: Volume 201 (Progress in Molecular Biology and Translational Science, Volume 201) - Tapa dura

Acerca del autor

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

De la contraportada

Bacteriophages (or phages) are ubiquitous in nature and the most abundant biological entities on our planet. It is a natural enemies of bacteria. Phages are obligate intracellular parasites and replicate inside the host either lysogenic or lytic mode after infection using the cellular machinery of a bacterium. On the basis of their anti-bacterial property and unique characteristics, phages are being comprehensively evaluated taxonomically. The accumulating genome sequences data of various phages are being provided an opportunity to researchers to annotate and characterise the various putative gene candidates to understand the molecular mechanisms involve in the lytic and lysogenic states.

In the early 1900s, Twort and d'Herelle discovered the phages, and it became an important factor for fighting pathogenic bacteria in disease treatments. Moreover, phage-based vaccination is being evolved as one of the most encouraging preventive approaches. Due to this, its related research got remarkable recognition. However, due to the rapid emergence of bacterial resistance on antibiotics, use of phage (phage therapy) could be a major motive of research. Because the most promising solutions lies in bacteriophages. This volume covers fundamental of bacteriophage, isolation, screening, synthetic phage, phage for diagnostic, directed evolution, host interaction and many. It has also covered phage for treatment of Escherichia coli, Klebsiella pneumoniae, Salmonella spp, Staphylococcus aureus and Acinetobacter baumannii. This volume is an excellent and informative text on phage and their use for treatment of bacterial infections. The main aim behind this volume is to highlight a number of aspects of the phage in a way that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.